Functions of RNAi Pathways in Ribosomal RNA Regulation

IF 3.6 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Non-Coding RNA Pub Date : 2024-03-29 DOI:10.3390/ncrna10020019

A. S. Shatskikh, E. Fefelova, M. Klenov

引用次数: 0

Abstract

Argonaute proteins, guided by small RNAs, play crucial roles in gene regulation and genome protection through RNA interference (RNAi)-related mechanisms. Ribosomal RNAs (rRNAs), encoded by repeated rDNA units, constitute the core of the ribosome being the most abundant cellular transcripts. rDNA clusters also serve as sources of small RNAs, which are loaded into Argonaute proteins and are able to regulate rDNA itself or affect other gene targets. In this review, we consider the impact of small RNA pathways, specifically siRNAs and piRNAs, on rRNA gene regulation. Data from diverse eukaryotic organisms suggest the potential involvement of small RNAs in various molecular processes related to the rDNA transcription and rRNA fate. Endogenous siRNAs are integral to the chromatin-based silencing of rDNA loci in plants and have been shown to repress rDNA transcription in animals. Small RNAs also play a role in maintaining the integrity of rDNA clusters and may function in the cellular response to rDNA damage. Studies on the impact of RNAi and small RNAs on rRNA provide vast opportunities for future exploration.

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核糖体 RNA 调控中的 RNAi 途径功能

Argonaute 蛋白在小 RNA 的引导下，通过与 RNA 干扰（RNAi）相关的机制，在基因调控和基因组保护方面发挥着至关重要的作用。由重复的 rDNA 单元编码的核糖体 RNA（rRNA）构成了核糖体的核心，是最丰富的细胞转录本。rDNA 簇也是小 RNA 的来源，小 RNA 被载入 Argonaute 蛋白，能够调控 rDNA 本身或影响其他基因靶标。在这篇综述中，我们将探讨小 RNA 途径，特别是 siRNA 和 piRNA 对 rRNA 基因调控的影响。来自不同真核生物的数据表明，小 RNA 可能参与了与 rDNA 转录和 rRNA 转归相关的各种分子过程。内源 siRNA 是植物中基于染色质的 rDNA 基因座沉默不可或缺的部分，在动物中也被证明能抑制 rDNA 的转录。小 RNA 还在维持 rDNA 簇的完整性方面发挥作用，并可能在细胞对 rDNA 损伤的反应中发挥作用。关于 RNAi 和小 RNA 对 rRNA 影响的研究为未来的探索提供了广阔的空间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Non-Coding RNA Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

6.70

自引率

4.70%

发文量

审稿时长

10 weeks

期刊介绍： Functional studies dealing with identification, structure-function relationships or biological activity of: small regulatory RNAs (miRNAs, siRNAs and piRNAs) associated with the RNA interference pathway small nuclear RNAs, small nucleolar and tRNAs derived small RNAs other types of small RNAs, such as those associated with splice junctions and transcription start sites long non-coding RNAs, including antisense RNAs, long ''intergenic'' RNAs, intronic RNAs and ''enhancer'' RNAs other classes of RNAs such as vault RNAs, scaRNAs, circular RNAs, 7SL RNAs, telomeric and centromeric RNAs regulatory functions of mRNAs and UTR-derived RNAs catalytic and allosteric (riboswitch) RNAs viral, transposon and repeat-derived RNAs bacterial regulatory RNAs, including CRISPR RNAS Analysis of RNA processing, RNA binding proteins, RNA signaling and RNA interaction pathways: DICER AGO, PIWI and PIWI-like proteins other classes of RNA binding and RNA transport proteins RNA interactions with chromatin-modifying complexes RNA interactions with DNA and other RNAs the role of RNA in the formation and function of specialized subnuclear organelles and other aspects of cell biology intercellular and intergenerational RNA signaling RNA processing structure-function relationships in RNA complexes RNA analyses, informatics, tools and technologies: transcriptomic analyses and technologies development of tools and technologies for RNA biology and therapeutics Translational studies involving long and short non-coding RNAs: identification of biomarkers development of new therapies involving microRNAs and other ncRNAs clinical studies involving microRNAs and other ncRNAs.

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