Mechanisms of nitric oxide in spinal cord injury

IF 4.7 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-03-28 DOI:10.4103/mgr.medgasres-d-23-00006
Jiahui Hao, Yang Ye, Guoguo Zhang, Haitao Shen, Jinquan Li, Gang Chen
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Abstract

Spinal cord injury (SCI) is a primary lesion of the spinal cord that results from external forces or diseases, accompanied by a cascade of secondary events. Nitric oxide, an endogenous gas that functions as a signaling molecule in the human body, plays a crucial role in vasodilation of smooth muscles, regulation of blood flow and pressure, and inflammatory response. This article provides a comprehensive overview of the involvement of nitric oxide in SCI and highlights recent advances in basic research on pharmacological agents that inhibit nitric oxide elevation after SCI, offering valuable insights for future therapeutic interventions targeting SCI.
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一氧化氮在脊髓损伤中的作用机制
脊髓损伤(SCI)是由外力或疾病导致的脊髓原发性损伤,并伴有一系列继发性事件。一氧化氮是一种内源性气体,在人体内起着信号分子的作用,在平滑肌血管扩张、血流和血压调节以及炎症反应中起着至关重要的作用。本文全面概述了一氧化氮在 SCI 中的参与情况,并重点介绍了抑制 SCI 后一氧化氮升高的药理药物基础研究的最新进展,为未来针对 SCI 的治疗干预提供了宝贵的见解。
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来源期刊
CiteScore
7.20
自引率
4.30%
发文量
567
期刊介绍: ACS Applied Electronic Materials is an interdisciplinary journal publishing original research covering all aspects of electronic materials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials science, engineering, optics, physics, and chemistry into important applications of electronic materials. Sample research topics that span the journal's scope are inorganic, organic, ionic and polymeric materials with properties that include conducting, semiconducting, superconducting, insulating, dielectric, magnetic, optoelectronic, piezoelectric, ferroelectric and thermoelectric. Indexed/​Abstracted: Web of Science SCIE Scopus CAS INSPEC Portico
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