A General Evaluation of the Cellular Role in Drug Release: A Clinical Review Study

Karami Mohammad Hossein, Abdouss Majid
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Abstract

Cells have emerged as highly promising vehicles for delivering drugs due to their unique advantages. They have the ability to bypass immune recognition, navigate biological barriers, and reach difficult-to-access tissues through sensing and active movement. Over the past couple of decades, extensive research has been conducted to understand how cell carriers can overcome biological barriers and influence drug effectiveness. This has resulted in the development of engineered cells for targeted drug delivery to specific tissues. Despite the presence of exciting developments, a comprehensive understanding of the challenges and potential strategies is necessary for the effective clinical application of cell-based drug carriers. This review provides an overview of recent progress and novel concepts in cell-based drug carriers, as well as their potential for translation into clinical practice. Additionally, we delve into important factors and emerging strategies for designing the next generation of cell-based delivery technologies, with a particular emphasis on achieving greater accuracy and targeted drug administration.
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细胞在药物释放中作用的总体评估:临床回顾研究
细胞因其独特的优势而成为极具前景的药物输送载体。它们能够绕过免疫识别,穿越生物屏障,并通过感知和主动运动到达难以进入的组织。过去几十年来,人们进行了大量研究,以了解细胞载体如何克服生物屏障并影响药物疗效。因此,人们开发出了用于向特定组织定向递送药物的工程细胞。尽管取得了令人兴奋的进展,但全面了解基于细胞的药物载体在临床上的有效应用所面临的挑战和潜在策略仍是必要的。本综述概述了细胞药物载体的最新进展和新概念,以及将其转化为临床实践的潜力。此外,我们还深入探讨了设计下一代细胞给药技术的重要因素和新兴策略,特别强调了实现更高的给药准确性和靶向性。
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