The effect of the new coronavirus infection on the human pancreas

S. V. Tarasenko, D. A. Glotov, O. D. Peskov, S. N. Sokolova, U. V. Zhuchkova, T. S. Rakhmaev, I. Bakonina, A. Bogomolov, D. O. Tyulenev, S. N. Brovkina, S. G. Bykova, S. V. Gurov
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Abstract

The aim of the study - is to study the effect of a new coronavirus infection on the human pancreas. Research materials. An analysis for blood α-amylase, as well as ultrasound of the abdominal cavity, namely the pancreas, was carried out. This study involved 20 patients, 10 had a concomitant disease in the form of diabetes mellitus and 10 without it. The results of the research. During the research, all patients had relatively the same dynamics of pancreatic lesions, without any pronounced manifestations of pancreatitis. The shift of analyses in favor of this pathology indicates more to the glucocorticosteroid therapy that patients received in the treatment of covid-19 coronavirus infection. Only one of the 20 patients studied had a classic manifestation of pancreatitis. Conclusions. Acute pancreatitis is a rare complication of COVID-19, and it is not often associated with this infection. Nevertheless, acute pancreatitis with SARS-CoV-2 infection is considered to have a higher risk of severe course and poor clinical outcomes, including the risk of organ dysfunction and higher inpatient mortality compared to patients with acute pancreatitis negative for SARS-CoV-2.
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新型冠状病毒感染对人类胰腺的影响
研究目的 - 研究新型冠状病毒感染对人类胰腺的影响。研究材料。对血液α-淀粉酶进行了分析,并对腹腔(即胰腺)进行了超声波检查。这项研究涉及 20 名患者,其中 10 人伴有糖尿病,10 人没有糖尿病。研究结果在研究过程中,所有患者的胰腺病变动态相对相同,没有任何明显的胰腺炎表现。分析结果更倾向于这种病理变化,这与患者在治疗柯维-19 冠状病毒感染时接受的糖皮质激素治疗有很大关系。在研究的 20 名患者中,只有一人有典型的胰腺炎表现。结论:急性胰腺炎是一种罕见的并发症。急性胰腺炎是COVID-19冠状病毒感染的罕见并发症,而且这种感染并不常见。然而,与 SARS-CoV-2 阴性的急性胰腺炎患者相比,感染 SARS-CoV-2 的急性胰腺炎患者出现严重病程和不良临床结果的风险更高,包括器官功能障碍的风险和更高的住院死亡率。
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