Norashikin Salleh, Mohd Muzamir Mahat, Sabrina M. Yahaya, Rosmamuhamadani Ramli
{"title":"Kinetic and Mechanism of Zerumbone Release from Cross-linked Gelatin-Zeolite Y Hybrid for Oral Anticancer Drug Delivery","authors":"Norashikin Salleh, Mohd Muzamir Mahat, Sabrina M. Yahaya, Rosmamuhamadani Ramli","doi":"10.37934/arfmts.115.1.181192","DOIUrl":null,"url":null,"abstract":"A hybrid of zeolite Y-gelatin film as an oral dosage form for the natural anticancer drug was achieved by homogenously incorporating the drug-loaded zeolite Y into the gelatin solution. Drug ability was analyzed using computational and experimental approaches, drug encapsulation efficiency via the BET method, and possible interactions by FTIR analyses. Zerumbone released was done in both pH 1.2 and pH 7.4 mimicking the human gastrointestinal tract conditions for 24 hrs and subjected to kinetics study via suitable mathematical models to determine what governs the drug release with the results indicating that a sustained delivery of once-daily oral dosage form could be achieved.","PeriodicalId":37460,"journal":{"name":"Journal of Advanced Research in Fluid Mechanics and Thermal Sciences","volume":" 966","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Advanced Research in Fluid Mechanics and Thermal Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37934/arfmts.115.1.181192","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Chemical Engineering","Score":null,"Total":0}
引用次数: 0
Abstract
A hybrid of zeolite Y-gelatin film as an oral dosage form for the natural anticancer drug was achieved by homogenously incorporating the drug-loaded zeolite Y into the gelatin solution. Drug ability was analyzed using computational and experimental approaches, drug encapsulation efficiency via the BET method, and possible interactions by FTIR analyses. Zerumbone released was done in both pH 1.2 and pH 7.4 mimicking the human gastrointestinal tract conditions for 24 hrs and subjected to kinetics study via suitable mathematical models to determine what governs the drug release with the results indicating that a sustained delivery of once-daily oral dosage form could be achieved.
期刊介绍：
This journal welcomes high-quality original contributions on experimental, computational, and physical aspects of fluid mechanics and thermal sciences relevant to engineering or the environment, multiphase and microscale flows, microscale electronic and mechanical systems; medical and biological systems; and thermal and flow control in both the internal and external environment.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
