Pharmacological Activities, Isolated Compounds, Toxicity, and Potential for New Drug Discovery from the Genus Leea

Purwaniati Purwaniati, R. E. Kartasasmita, Muhammad Insanu, M. Iwo
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Abstract

The genus Leea is a genus of medicinal plants. Half of this genus species are traditionally used to treat various ailments. This genus also holds promise for molecules that have the potential to be used as drugs or lead compounds in the discovery of a new drug. So far, 66 compounds have been isolated from this genus, 46 known to have pharmacological activity. Antioxidant, antimicrobial, anti-inflammatory and anticancer are the pharmacological activities most frequently found in these compounds. Although the toxicity studies are still limited to chronic toxicity tests showing low toxicity potential. The fact that various pharmacological activities and low potential make toxicity makes this plant worthy of continued study. The potential to possibility drugs from this genus is also huge.
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韭菜属植物的药理活性、分离化合物、毒性和新药开发潜力
韭菜属是一个药用植物属。该属的一半物种传统上用于治疗各种疾病。该属植物也有望发现有潜力用作药物的分子或发现新药物的先导化合物。迄今为止,已从该属植物中分离出 66 种化合物,其中 46 种已知具有药理活性。抗氧化、抗菌、抗炎和抗癌是这些化合物中最常见的药理活性。虽然毒性研究仍局限于慢性毒性试验,但显示其毒性潜力较低。各种药理活性和低潜在毒性使这种植物值得继续研究。从该属植物中提取药物的潜力也是巨大的。
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