Glycemic control in children with type 1 diabetes: Insulin pump therapy versus multiple daily injections

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-03-25 DOI:10.29333/ejgm/14403

A. Durmanova, Gulnur Slyamova, M. Rakhimzhanova, A. Gusmanov, Gulmira Zhakanova, Gulmira Abduakhassova, Assel Issabayeva, Assiya Nurgaliyeva, Alina Alzhaxina, Aigerim Umerzakova, Kristina Fedoskina, Marina Kalzhanova, Makhabbat Serikbayeva, Altay Nabiyev, A. Gaipov

{"title":"Glycemic control in children with type 1 diabetes: Insulin pump therapy versus multiple daily injections","authors":"A. Durmanova, Gulnur Slyamova, M. Rakhimzhanova, A. Gusmanov, Gulmira Zhakanova, Gulmira Abduakhassova, Assel Issabayeva, Assiya Nurgaliyeva, Alina Alzhaxina, Aigerim Umerzakova, Kristina Fedoskina, Marina Kalzhanova, Makhabbat Serikbayeva, Altay Nabiyev, A. Gaipov","doi":"10.29333/ejgm/14403","DOIUrl":null,"url":null,"abstract":"While many studies compared multiple daily injections (MDI) and insulin pump therapy on various clinical outcomes, the results remain inconclusive. This multicenter retrospective cohort study included 175 patients and aimed to evaluate the effects of different insulin therapy methods on various clinical outcomes, including hemoglobin A1c (HbA1c), total daily insulin dosage, body mass index, glomerular filtration rate, in pediatric patients with type 1 diabetes. In a linear mixed-effects regression analysis, a statistically significant interaction between time and treatment type on HbA1c was found. It suggested significantly higher reduction of HbA1c values between 12-month visit and baseline in the group receiving MDIs compared to insulin pump therapy. Patients using MDIs observed higher reduction of HbA1c levels and lower total daily insulin dose relative to insulin pump therapy group. Other changes of clinical indicators were the same for group of patients. Various studies report controversial results on long term effects of these treatments on HbA1c values necessitating large population-based cohort studies in this field.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" 33","pages":""},"PeriodicalIF":17.7000,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29333/ejgm/14403","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

While many studies compared multiple daily injections (MDI) and insulin pump therapy on various clinical outcomes, the results remain inconclusive. This multicenter retrospective cohort study included 175 patients and aimed to evaluate the effects of different insulin therapy methods on various clinical outcomes, including hemoglobin A1c (HbA1c), total daily insulin dosage, body mass index, glomerular filtration rate, in pediatric patients with type 1 diabetes. In a linear mixed-effects regression analysis, a statistically significant interaction between time and treatment type on HbA1c was found. It suggested significantly higher reduction of HbA1c values between 12-month visit and baseline in the group receiving MDIs compared to insulin pump therapy. Patients using MDIs observed higher reduction of HbA1c levels and lower total daily insulin dose relative to insulin pump therapy group. Other changes of clinical indicators were the same for group of patients. Various studies report controversial results on long term effects of these treatments on HbA1c values necessitating large population-based cohort studies in this field.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

1 型糖尿病儿童的血糖控制：胰岛素泵疗法与每日多次注射疗法的比较

尽管许多研究比较了每日多次注射（MDI）和胰岛素泵疗法对各种临床结果的影响，但结果仍不确定。这项多中心回顾性队列研究纳入了175名患者，旨在评估不同胰岛素治疗方法对1型糖尿病儿科患者血红蛋白A1c（HbA1c）、每日胰岛素总用量、体重指数、肾小球滤过率等各种临床结果的影响。在线性混合效应回归分析中发现，时间和治疗类型对 HbA1c 的影响具有显著的统计学交互作用。结果表明，与胰岛素泵疗法相比，使用计量吸入器的组别在 12 个月访视和基线之间的 HbA1c 值下降幅度明显更高。与胰岛素泵治疗组相比，使用计量吸入器的患者 HbA1c 水平降低幅度更大，每日胰岛素总剂量更低。各组患者的其他临床指标变化相同。关于这些疗法对 HbA1c 值的长期影响，多项研究报告的结果存在争议，因此有必要在该领域开展大规模的人群队列研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.