Diabesity is a modern term that describes the coexistence of adverse health effects of diabetes mellitus and obesity and indicates a causal pathophysiological relationship between the two phenomena. The progression of diabesity leads to a deterioration of multiple organs and systems. Effective intervention for patients with diabesity must include optimal obesity therapy to prevent secondary complications. Metabolic surgery is the most effective and sustainable therapy for severe obesity and the elimination or prevention of many associated diseases, including type 2 diabetes mellitus, hypertension, sleep apnea, heart disease, and certain cancers. This review provides an up-to-date overview of surgical interventions for obesity, particularly the development of metabolic surgery. It evaluates different scoring systems for evidence-based selection of metabolic surgery based on disease severity. We reviewed different predictive scoring systems for better evidence-based selection of the best metabolic surgery for patients with diabesity. We found that medication type, fasting insulin level, and C-peptide influence the outcomes of different types of metabolic surgery and heterogeneous remission rates. There are different predictive scoring systems for evidence-based selection of the best metabolic surgery, either sleeve or mini-bypass, that will ensure the highest chance of diabetes remission. Using the metabolic score calculator is a useful tool to help medical specialists determine the optimal treatment strategy for a particular patient. More research is needed before we can agree on the ideal bariatric procedure that offers the highest chance of remission with the lowest incidence of hypoglycemia.
肥胖症是一个现代术语，它描述了糖尿病和肥胖症同时存在对健康的不利影响，并表明这两种现象之间存在因果病理生理学关系。肥胖症的发展会导致多个器官和系统的衰退。对肥胖症患者的有效干预必须包括最佳的肥胖症治疗，以防止继发并发症。代谢手术是治疗严重肥胖症以及消除或预防许多相关疾病（包括 2 型糖尿病、高血压、睡眠呼吸暂停、心脏病和某些癌症）的最有效、最持久的疗法。本综述概述了肥胖症外科干预的最新情况，尤其是代谢外科的发展。它评估了根据疾病严重程度循证选择代谢手术的不同评分系统。我们回顾了不同的预测评分系统，以便更好地为肥胖症患者循证选择最佳代谢手术。我们发现，药物类型、空腹胰岛素水平和 C 肽会影响不同类型代谢手术的结果和不同的缓解率。有不同的预测评分系统可用于循证选择最佳代谢手术（袖状手术或迷你旁路手术），以确保获得最高的糖尿病缓解率。使用代谢评分计算器是一种有用的工具，可帮助医学专家为特定患者确定最佳治疗策略。我们还需要进行更多的研究，才能就理想的减肥手术达成一致意见，从而提供最高的缓解几率和最低的低血糖发生率。
{"title":"Metabolic surgery in patients with diabesity: A review of the historical backgrounds and scoring systems","authors":"W. Albaker, M. Al-Hariri","doi":"10.29333/ejgm/14093","DOIUrl":"https://doi.org/10.29333/ejgm/14093","url":null,"abstract":"Diabesity is a modern term that describes the coexistence of adverse health effects of diabetes mellitus and obesity and indicates a causal pathophysiological relationship between the two phenomena. The progression of diabesity leads to a deterioration of multiple organs and systems. Effective intervention for patients with diabesity must include optimal obesity therapy to prevent secondary complications. Metabolic surgery is the most effective and sustainable therapy for severe obesity and the elimination or prevention of many associated diseases, including type 2 diabetes mellitus, hypertension, sleep apnea, heart disease, and certain cancers. This review provides an up-to-date overview of surgical interventions for obesity, particularly the development of metabolic surgery. It evaluates different scoring systems for evidence-based selection of metabolic surgery based on disease severity. We reviewed different predictive scoring systems for better evidence-based selection of the best metabolic surgery for patients with diabesity. We found that medication type, fasting insulin level, and C-peptide influence the outcomes of different types of metabolic surgery and heterogeneous remission rates. There are different predictive scoring systems for evidence-based selection of the best metabolic surgery, either sleeve or mini-bypass, that will ensure the highest chance of diabetes remission. Using the metabolic score calculator is a useful tool to help medical specialists determine the optimal treatment strategy for a particular patient. More research is needed before we can agree on the ideal bariatric procedure that offers the highest chance of remission with the lowest incidence of hypoglycemia.","PeriodicalId":44930,"journal":{"name":"Electronic Journal of General Medicine","volume":"20 7","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139388535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alikhan Karymsakov, Faye Foster, Lyazzat Toleubekova, Nurgul Yegembayeva, A. Gaipov, M. Aljofan
Aim: The aim is to clarify the prevalence of nonadherence to antidiabetic therapies among type 2 diabetes mellitus (T2DM) patients and identify its causes. Methods: A three-part questionnaire (general background, Knowledge-Attitude-Practice section, and non-adherence reasons) was developed. In total 324 diabetic patients were surveyed via telephone. The evaluation of patient adherence included both direct questions on adherence and a summary of patient responses to non-adherence comments. The analysis was performed on StataCorp Stata 14.2, and included descriptive analysis, simple and multivariate logistic regression. Findings: Among the sociodemographic variables, age group, work level, and alcohol consumption may influence medication adherence. The comorbidity status of patients was also of relevance. Both variables had stronger relationships with adherence to anti-diabetic treatments compared to those with no comorbidities or no additional medicines. A strength of the study is that it addresses various medical diseases and attitudes about them, as well as a wide range of causes for non-adherence to non-diabetic medications.
目的：旨在明确 2 型糖尿病（T2DM）患者不坚持抗糖尿病治疗的普遍性，并找出其原因：编制了一份由三部分组成的调查问卷（一般背景、知识-态度-实践部分和不坚持治疗的原因）。共通过电话对 324 名糖尿病患者进行了调查。对患者依从性的评估既包括关于依从性的直接问题，也包括患者对不依从性意见的答复摘要。分析使用 StataCorp Stata 14.2 进行，包括描述性分析、简单和多变量逻辑回归：在社会人口学变量中，年龄组、工作水平和饮酒量可能会影响服药依从性。患者的合并症状况也与此有关。与无并发症或无额外药物的患者相比，这两个变量与坚持抗糖尿病治疗的关系更为密切。这项研究的优势在于它涉及了各种内科疾病和对这些疾病的态度，以及导致不坚持服用非糖尿病药物的各种原因。
{"title":"The nonadherence to prescriptions among type 2 diabetes patients, and its determining factors","authors":"Alikhan Karymsakov, Faye Foster, Lyazzat Toleubekova, Nurgul Yegembayeva, A. Gaipov, M. Aljofan","doi":"10.29333/ejgm/14094","DOIUrl":"https://doi.org/10.29333/ejgm/14094","url":null,"abstract":"Aim: The aim is to clarify the prevalence of nonadherence to antidiabetic therapies among type 2 diabetes mellitus (T2DM) patients and identify its causes.\u0000Methods: A three-part questionnaire (general background, Knowledge-Attitude-Practice section, and non-adherence reasons) was developed. In total 324 diabetic patients were surveyed via telephone. The evaluation of patient adherence included both direct questions on adherence and a summary of patient responses to non-adherence comments. The analysis was performed on StataCorp Stata 14.2, and included descriptive analysis, simple and multivariate logistic regression.\u0000Findings: Among the sociodemographic variables, age group, work level, and alcohol consumption may influence medication adherence. The comorbidity status of patients was also of relevance. Both variables had stronger relationships with adherence to anti-diabetic treatments compared to those with no comorbidities or no additional medicines. A strength of the study is that it addresses various medical diseases and attitudes about them, as well as a wide range of causes for non-adherence to non-diabetic medications.","PeriodicalId":44930,"journal":{"name":"Electronic Journal of General Medicine","volume":"1 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139389675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maykon Jhuly Martins de Paiva, Guilherme Nobre L do Nascimento, Iangla Araújo de Melo Damasceno, Lucas Nordhoff Barcelos Cunha, Jeremias Emanoel de Sousa Pimentel, L. T. F. e Silva, Tayslane Dias Castro, D. Silveira
Amaryllidaceae alkaloids have attracted significant attention in cancer research for their potential antitumor properties. To date, numerous studies have investigated the effects of these alkaloids on cancer cell lines, but a comprehensive synthesis of the existing evidence through a literature review is warranted. This article presents a comprehensive literature review aimed at evaluating the antitumor effects of amaryllidaceae alkaloids on various cancer cell lines and elucidating the underlying mechanisms of action. A search was conducted in major scientific databases, including Google Scholar, PubMed, Scopus, and Web of Science, to identify relevant studies published between 2013 and 2023. Studies that examined the antitumor effects of amaryllidaceae alkaloids on cancer cell lines were included in the review. Data were extracted, analyzed, and synthesized to provide an in-depth overview of the findings. The alkaloids exhibited potent cytotoxicity and suppressed cell proliferation in a concentration-dependent manner. Mechanistic investigations unveiled that amaryllidaceae alkaloids induced apoptosis, cell cycle arrest, and hindered angiogenesis in cancer cells. Moreover, they demonstrated favorable selectivity towards cancer cells, sparing normal cells, suggesting potential as targeted therapies. This literature review consolidates and critically appraises the available evidence on the antitumor effects of amaryllidaceae alkaloids on cancer cell lines. The findings underscore their potential as promising candidates for further exploration in cancer therapeutics. Future preclinical and clinical studies are vital to advance their development and translation into effective anticancer drugs.
金盏花科生物碱因其潜在的抗肿瘤特性而在癌症研究中备受关注。迄今为止，已有许多研究调查了这些生物碱对癌细胞系的影响，但有必要通过文献综述对现有证据进行全面总结。本文介绍了一篇全面的文献综述，旨在评估金盏花科生物碱对各种癌细胞系的抗肿瘤作用，并阐明其潜在的作用机制。我们在谷歌学术、PubMed、Scopus 和 Web of Science 等主要科学数据库中进行了检索，以确定 2013 年至 2023 年间发表的相关研究。综述纳入了研究金盏花科生物碱对癌细胞系抗肿瘤作用的研究。对数据进行了提取、分析和综合，以深入概述研究结果。这些生物碱具有很强的细胞毒性，并以浓度依赖的方式抑制细胞增殖。机理研究发现，金盏花科生物碱能诱导癌细胞凋亡、细胞周期停滞并阻碍血管生成。此外，它们对癌细胞具有良好的选择性，而对正常细胞则无影响，这表明它们具有靶向治疗的潜力。这篇文献综述整合并严格评估了有关金盏花科生物碱对癌细胞株抗肿瘤作用的现有证据。研究结果表明，这些生物碱有望成为癌症疗法的候选药物。未来的临床前和临床研究对于推动其发展并将其转化为有效的抗癌药物至关重要。
{"title":"Antitumor evaluation of amaryllidaceae alkaloids on cancer cell lines: A literature review","authors":"Maykon Jhuly Martins de Paiva, Guilherme Nobre L do Nascimento, Iangla Araújo de Melo Damasceno, Lucas Nordhoff Barcelos Cunha, Jeremias Emanoel de Sousa Pimentel, L. T. F. e Silva, Tayslane Dias Castro, D. Silveira","doi":"10.29333/ejgm/14040","DOIUrl":"https://doi.org/10.29333/ejgm/14040","url":null,"abstract":"Amaryllidaceae alkaloids have attracted significant attention in cancer research for their potential antitumor properties. To date, numerous studies have investigated the effects of these alkaloids on cancer cell lines, but a comprehensive synthesis of the existing evidence through a literature review is warranted. This article presents a comprehensive literature review aimed at evaluating the antitumor effects of amaryllidaceae alkaloids on various cancer cell lines and elucidating the underlying mechanisms of action. A search was conducted in major scientific databases, including Google Scholar, PubMed, Scopus, and Web of Science, to identify relevant studies published between 2013 and 2023. Studies that examined the antitumor effects of amaryllidaceae alkaloids on cancer cell lines were included in the review. Data were extracted, analyzed, and synthesized to provide an in-depth overview of the findings. The alkaloids exhibited potent cytotoxicity and suppressed cell proliferation in a concentration-dependent manner. Mechanistic investigations unveiled that amaryllidaceae alkaloids induced apoptosis, cell cycle arrest, and hindered angiogenesis in cancer cells. Moreover, they demonstrated favorable selectivity towards cancer cells, sparing normal cells, suggesting potential as targeted therapies. This literature review consolidates and critically appraises the available evidence on the antitumor effects of amaryllidaceae alkaloids on cancer cell lines. The findings underscore their potential as promising candidates for further exploration in cancer therapeutics. Future preclinical and clinical studies are vital to advance their development and translation into effective anticancer drugs.","PeriodicalId":44930,"journal":{"name":"Electronic Journal of General Medicine","volume":"53 26","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139126768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohd Firdaus Abdul Mubing, Razlina Abdul Rahman, Salziyan Badrin, Hasni Ibrahim
Pachydermoperiostosis (PDP), also known as Touraine-Solente-Gole syndrome or primary hypertrophic osteoarthropathy, is a very rare disease mainly characterized by pachyderma, finger clubbing, hyperhidrosis, and periostosis. We reported a case of a patient who suffered from gradual pain and enlargement of both hands and feet for 25 years despite receiving treatment from multiple clinics. He also experienced gradual abnormal changes in his face and scalp. Radiographic images of the lower limbs revealed the presence of subperiosteal bone growth and periosteal hypertrophy. The diagnosis of complete PDP was made late due to its rarity and the unfamiliarity of medical practitioners with the diagnosis. This case highlighted the need for medical practitioners to be aware of rare diseases so that patients may be diagnosed and treated earlier and thereby relieving their anxiety and improve their quality of life.
{"title":"Complete pachydermoperiostosis: A case report","authors":"Mohd Firdaus Abdul Mubing, Razlina Abdul Rahman, Salziyan Badrin, Hasni Ibrahim","doi":"10.29333/ejgm/13900","DOIUrl":"https://doi.org/10.29333/ejgm/13900","url":null,"abstract":"Pachydermoperiostosis (PDP), also known as Touraine-Solente-Gole syndrome or primary hypertrophic osteoarthropathy, is a very rare disease mainly characterized by pachyderma, finger clubbing, hyperhidrosis, and periostosis. We reported a case of a patient who suffered from gradual pain and enlargement of both hands and feet for 25 years despite receiving treatment from multiple clinics. He also experienced gradual abnormal changes in his face and scalp. Radiographic images of the lower limbs revealed the presence of subperiosteal bone growth and periosteal hypertrophy. The diagnosis of complete PDP was made late due to its rarity and the unfamiliarity of medical practitioners with the diagnosis. This case highlighted the need for medical practitioners to be aware of rare diseases so that patients may be diagnosed and treated earlier and thereby relieving their anxiety and improve their quality of life.","PeriodicalId":44930,"journal":{"name":"Electronic Journal of General Medicine","volume":"5 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139129754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Beloborodov, V. Vorobev, A. Kalyagin, Svetlana Sokolova, I. Shaderkin, M. Firsov, D. Laletin
Purpose: The study aims to analyze the enhanced recovery protocol’s (ERP) effectiveness in a comparative study of elective surgeries for ureteropelvic junction obstruction (UPJO). Methods: The prospective study included 30 patients with UPJO who underwent laparoscopic pyeloplasty in 2018-2021. Results: Postoperative complications developed rarely, and their frequency and severity were comparable. Independent predictors of UPJO recurrence were the spine osteochondrosis >II period (HR 13.97; 95% CI 1.26; 154.8; p=0.032), the concretions self-discharge (HR 28.49; 95% CI 1.78; 455.62; p=0.018), surgical operation duration > 110 minutes (HR 44.7; 95% CI 3.95; 505.4; p=0.002) and previous nephrostomy (HR 1.07; 95% CI 1.02; 1.13; p=0.002). Conclusions: In the surgical treatment of UPJO, it is advisable to use ERPs, as this allows achieving a better treatment quality with comparable results.
目的：本研究旨在通过对输尿管盆腔交界处梗阻（UPJO）择期手术的比较研究，分析增强恢复方案（ERP）的有效性。方法：前瞻性研究纳入2018-2021年接受腹腔镜肾盂成形术的30例UPJO患者。结果：术后并发症很少发生：术后并发症很少发生，其发生频率和严重程度相当。UPJO复发的独立预测因素为脊柱骨软化>II期（HR 13.97; 95% CI 1.26; 154.8; p=0.032）、凝结物自排（HR 28.49; 95% CI 1.78；455.62；P=0.018）、手术操作时间>110分钟（HR 44.7；95% CI 3.95；505.4；P=0.002）和既往肾造瘘术（HR 1.07；95% CI 1.02；1.13；P=0.002）。结论在UPJO的手术治疗中，最好使用ERP，因为这样可以在取得可比效果的同时获得更好的治疗质量。
{"title":"Outcomes of laparoscopic pyeloplasty and impact of an enhanced recovery protocol","authors":"V. Beloborodov, V. Vorobev, A. Kalyagin, Svetlana Sokolova, I. Shaderkin, M. Firsov, D. Laletin","doi":"10.29333/ejgm/14020","DOIUrl":"https://doi.org/10.29333/ejgm/14020","url":null,"abstract":"Purpose: The study aims to analyze the enhanced recovery protocol’s (ERP) effectiveness in a comparative study of elective surgeries for ureteropelvic junction obstruction (UPJO). Methods: The prospective study included 30 patients with UPJO who underwent laparoscopic pyeloplasty in 2018-2021. Results: Postoperative complications developed rarely, and their frequency and severity were comparable. Independent predictors of UPJO recurrence were the spine osteochondrosis >II period (HR 13.97; 95% CI 1.26; 154.8; p=0.032), the concretions self-discharge (HR 28.49; 95% CI 1.78; 455.62; p=0.018), surgical operation duration > 110 minutes (HR 44.7; 95% CI 3.95; 505.4; p=0.002) and previous nephrostomy (HR 1.07; 95% CI 1.02; 1.13; p=0.002). Conclusions: In the surgical treatment of UPJO, it is advisable to use ERPs, as this allows achieving a better treatment quality with comparable results.","PeriodicalId":44930,"journal":{"name":"Electronic Journal of General Medicine","volume":"21 21","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139129711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohannad Adel Sayah, A. Oglat, M. Matjafri, A. Abukonna, Marwan Alshipli
Purpose: The study aims to evaluate precisely influence of temperature on the acoustical and physical properties of blood mimicking fluid (BMF) phantom made of polymer material. Materials & methods: Propylene glycol (PG) and polyethylene glycol (PEG) were fabricated to create artificial blood phantom. Acoustic (speed and attenuation) and physical properties (density and viscosity) of BMF were tested at specific temperatures of range 22 °C, 25 °C, 35 °C, 36 °C, and 37 °C using ultrasound signals. Results: At center frequency of 5 MHz, pulse-echo allows to acoustical (speed and attenuation) and physical (density and viscosity) values to be linearly decreased with increasing of temperature. The difference in values of speed, attenuation, density, and viscosity was nuance (±0.01, ±0.001, ±0.005, and ±0.151), respectively. Conclusions: Temperature test of range 22Co-37Co have nuance influence (±0.01, ±0.001, ±0.005, and ±0.151) on acoustical and physical properties when BMF phantom of special material of PG and PEG was used. This nuance influence may be taken in account in quality assurance of ultrasound imaging system.
{"title":"Precisely evaluation of temperature influence on artificial blood phantom properties made of polymers using ultrasound signals","authors":"Mohannad Adel Sayah, A. Oglat, M. Matjafri, A. Abukonna, Marwan Alshipli","doi":"10.29333/ejgm/13898","DOIUrl":"https://doi.org/10.29333/ejgm/13898","url":null,"abstract":"Purpose: The study aims to evaluate precisely influence of temperature on the acoustical and physical properties of blood mimicking fluid (BMF) phantom made of polymer material. Materials & methods: Propylene glycol (PG) and polyethylene glycol (PEG) were fabricated to create artificial blood phantom. Acoustic (speed and attenuation) and physical properties (density and viscosity) of BMF were tested at specific temperatures of range 22 °C, 25 °C, 35 °C, 36 °C, and 37 °C using ultrasound signals. Results: At center frequency of 5 MHz, pulse-echo allows to acoustical (speed and attenuation) and physical (density and viscosity) values to be linearly decreased with increasing of temperature. The difference in values of speed, attenuation, density, and viscosity was nuance (±0.01, ±0.001, ±0.005, and ±0.151), respectively. Conclusions: Temperature test of range 22Co-37Co have nuance influence (±0.01, ±0.001, ±0.005, and ±0.151) on acoustical and physical properties when BMF phantom of special material of PG and PEG was used. This nuance influence may be taken in account in quality assurance of ultrasound imaging system.","PeriodicalId":44930,"journal":{"name":"Electronic Journal of General Medicine","volume":"37 16","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139125678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Mechanical neck pain (MNP) affects all age groups, it has a substantial physical, psychological, and economic impact, especially in elderly. This study aimed to evaluate effect of addition of magnetic therapy (MT) to exercise versus exercise therapy alone on neck pain (NP), proprioception, and balance in elderly patients with chronic MNP. Materials & Methods: 50 elderly patients with chronic MNP were assigned to magnetic group (25 patients who practiced exercise program for 35-40 minutes/session three sessions per week for four weeks in addition exposure to MT for 20 minutes each session three sessions per week for four weeks) and control group (25 patients who practiced only the exercise program). The severity of pain, cervical joint position sense (JPS) and balance performance were measured by using the visual analogue scale (VAS) goniometer and the both single-leg stance time (SLST), and timed up and go (TUG) tests, respectively. ANOVA and Independent t-tests were used to determine significant differences within and between two groups for normal variables, whereas the Mann-Whitney and Kruskal-Wallis tests were used for not normal variables. Results: The results show significant improvements in VAS, SLST (with open and closed eyes), TUG, and JPS after interventions in both groups, p-value <0.05, while addition of MT to exercise program induced only significant differences in VAS, SLST (with open & closed eyes), TUG, except JPS, p-value = 0.002, 0.047 & 0.037, 0.001, and 0.928 respectively, in favor to the magnetic group. Conclusions: Multi-dimensional exercise program is effective in relieving NP and improving balance in elderly with MNP, addition of MT to exercise program could induce superior effects only on pain and balance for elderly patients with MNP.
{"title":"Effectiveness of magnetic therapy versus exercise in elderly patients with chronic mechanical neck pain: A randomized clinical trial","authors":"Randa Mohammed Awad Almasri, A. Shanb","doi":"10.29333/ejgm/14018","DOIUrl":"https://doi.org/10.29333/ejgm/14018","url":null,"abstract":"Background: Mechanical neck pain (MNP) affects all age groups, it has a substantial physical, psychological, and economic impact, especially in elderly. This study aimed to evaluate effect of addition of magnetic therapy (MT) to exercise versus exercise therapy alone on neck pain (NP), proprioception, and balance in elderly patients with chronic MNP. Materials & Methods: 50 elderly patients with chronic MNP were assigned to magnetic group (25 patients who practiced exercise program for 35-40 minutes/session three sessions per week for four weeks in addition exposure to MT for 20 minutes each session three sessions per week for four weeks) and control group (25 patients who practiced only the exercise program). The severity of pain, cervical joint position sense (JPS) and balance performance were measured by using the visual analogue scale (VAS) goniometer and the both single-leg stance time (SLST), and timed up and go (TUG) tests, respectively. ANOVA and Independent t-tests were used to determine significant differences within and between two groups for normal variables, whereas the Mann-Whitney and Kruskal-Wallis tests were used for not normal variables. Results: The results show significant improvements in VAS, SLST (with open and closed eyes), TUG, and JPS after interventions in both groups, p-value <0.05, while addition of MT to exercise program induced only significant differences in VAS, SLST (with open & closed eyes), TUG, except JPS, p-value = 0.002, 0.047 & 0.037, 0.001, and 0.928 respectively, in favor to the magnetic group. Conclusions: Multi-dimensional exercise program is effective in relieving NP and improving balance in elderly with MNP, addition of MT to exercise program could induce superior effects only on pain and balance for elderly patients with MNP.","PeriodicalId":44930,"journal":{"name":"Electronic Journal of General Medicine","volume":"13 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139125993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Kharaba, A. Jarab, W. Al-Qerem, Y. Alfoteih, M. Alhamaidah, Diana Malaeb, Mahmood Alibadah, M. Barakat
Background: Corticosteroid therapy has been associated with detrimental consequences such as cardiovascular problems and immunosuppression. Aims & objectives: This study aimed to assess the public knowledge, attitudes, and practice surrounding the use of corticosteroids in the United Arab Emirates (UAE) during the COVID-19 pandemic. Methods: This was a cross-sectional study carried out among the general population of the UAE from March to July 2022. A self-administered online survey was used, which included questions about participants’ socio-demographics, health status, and knowledge regarding corticosteroids. Eligibility criteria included participants aged>18 years or older and could read and respond to the questionnaire. Results: The study involved 583 participants, where the majority were mostly males living in urban areas. Nearly half had a bachelor’s degree, and 36.9% worked in the health sector. Around 55.0% of the participants had a high level of knowledge about corticosteroids, while more than half had a negative attitude towards them. The most frequently reported reason for using corticosteroids was dermatological diseases. Males with lower education levels, and who had not been infected with COVID-19 had lower odds of having a high level of knowledge about corticosteroids. Furthermore, older participants and those with a lower education level had a more negative attitude towards corticosteroids. Conclusions: This study showed gaps in knowledge and unfavorable attitude toward use of corticosteroids. Age, gender, working field, education level, residential area, having a chronic disease, being infected with COVID-19, and knowledge level were significantly associated with knowledge, attitude, and/or practice of corticosteroid use.
{"title":"What factors shape public knowledge, attitudes, and practices of corticosteroid use in the UAE during the COVID-19 pandemic?","authors":"Z. Kharaba, A. Jarab, W. Al-Qerem, Y. Alfoteih, M. Alhamaidah, Diana Malaeb, Mahmood Alibadah, M. Barakat","doi":"10.29333/ejgm/14019","DOIUrl":"https://doi.org/10.29333/ejgm/14019","url":null,"abstract":"Background: Corticosteroid therapy has been associated with detrimental consequences such as cardiovascular problems and immunosuppression. Aims & objectives: This study aimed to assess the public knowledge, attitudes, and practice surrounding the use of corticosteroids in the United Arab Emirates (UAE) during the COVID-19 pandemic. Methods: This was a cross-sectional study carried out among the general population of the UAE from March to July 2022. A self-administered online survey was used, which included questions about participants’ socio-demographics, health status, and knowledge regarding corticosteroids. Eligibility criteria included participants aged>18 years or older and could read and respond to the questionnaire. Results: The study involved 583 participants, where the majority were mostly males living in urban areas. Nearly half had a bachelor’s degree, and 36.9% worked in the health sector. Around 55.0% of the participants had a high level of knowledge about corticosteroids, while more than half had a negative attitude towards them. The most frequently reported reason for using corticosteroids was dermatological diseases. Males with lower education levels, and who had not been infected with COVID-19 had lower odds of having a high level of knowledge about corticosteroids. Furthermore, older participants and those with a lower education level had a more negative attitude towards corticosteroids. Conclusions: This study showed gaps in knowledge and unfavorable attitude toward use of corticosteroids. Age, gender, working field, education level, residential area, having a chronic disease, being infected with COVID-19, and knowledge level were significantly associated with knowledge, attitude, and/or practice of corticosteroid use.","PeriodicalId":44930,"journal":{"name":"Electronic Journal of General Medicine","volume":"44 7","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139127336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rimma Suatbayeva, D. Toguzbayeva, Saule Taukeleva, Zhanetta Mukanova, Magzhan Sadykov
Background: One of the greatest difficulties of the hearing impaired is understanding speech, especially in the presence of competitive noise. Speech perception issues are a common difficulty for those who have hearing loss. Poor speech perception is the most frequent cause of seeking hearing treatment. The most extensively used treatment to enhance speech perception is hearing aids or other assistive devices. Aim: To evaluate the effect of hearing aid methods on the speech perception of patients with hearing loss. Methods: We conducted our study based on PRISMA recommendations and guidelines. We searched Cochrane, PubMed, Scopus, and Web of Science for relevant clinical trials and prospective observational studies. Clinical trials were assessed according to Cochrane’s risk of bias tool, while observational studies were evaluated according to the National Heart, Lung, and Blood Institute. We involved the following outcomes: speech recognition thresholds, word recognition score (WRS) in noise, and WRS in quiet. Results: Six studies met the eligibility criteria for our meta-analysis. We found that hearing aids can cause an increase in WRS in noise (mean difference [MD]=18.32 [3.08, 33.55], p=0.02) and WRS in quiet (MD=45.13 [7.79, 82.46], p=0.02). In addition, hearing aids lead to a decrease in speech recognition thresholds (MD=45.13 [7.79, 82.46], p=0.02). Conclusions: Hearing aids are an effective treatment for patients with hearing loss. They can significantly improve speech perception (WRS) in quiet and noisy environments and provide other benefits, such as improved communication, increased safety, and better cognitive function. If you or someone you know has hearing loss, it is essential to speak with a healthcare professional about the benefits of using hearing aids.
{"title":"Speech perception and parameters of speech audiometry after hearing aid: Systematic review and meta-analysis","authors":"Rimma Suatbayeva, D. Toguzbayeva, Saule Taukeleva, Zhanetta Mukanova, Magzhan Sadykov","doi":"10.29333/ejgm/14041","DOIUrl":"https://doi.org/10.29333/ejgm/14041","url":null,"abstract":"Background: One of the greatest difficulties of the hearing impaired is understanding speech, especially in the presence of competitive noise. Speech perception issues are a common difficulty for those who have hearing loss. Poor speech perception is the most frequent cause of seeking hearing treatment. The most extensively used treatment to enhance speech perception is hearing aids or other assistive devices. Aim: To evaluate the effect of hearing aid methods on the speech perception of patients with hearing loss. Methods: We conducted our study based on PRISMA recommendations and guidelines. We searched Cochrane, PubMed, Scopus, and Web of Science for relevant clinical trials and prospective observational studies. Clinical trials were assessed according to Cochrane’s risk of bias tool, while observational studies were evaluated according to the National Heart, Lung, and Blood Institute. We involved the following outcomes: speech recognition thresholds, word recognition score (WRS) in noise, and WRS in quiet. Results: Six studies met the eligibility criteria for our meta-analysis. We found that hearing aids can cause an increase in WRS in noise (mean difference [MD]=18.32 [3.08, 33.55], p=0.02) and WRS in quiet (MD=45.13 [7.79, 82.46], p=0.02). In addition, hearing aids lead to a decrease in speech recognition thresholds (MD=45.13 [7.79, 82.46], p=0.02). Conclusions: Hearing aids are an effective treatment for patients with hearing loss. They can significantly improve speech perception (WRS) in quiet and noisy environments and provide other benefits, such as improved communication, increased safety, and better cognitive function. If you or someone you know has hearing loss, it is essential to speak with a healthcare professional about the benefits of using hearing aids.","PeriodicalId":44930,"journal":{"name":"Electronic Journal of General Medicine","volume":"15 21","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139129242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ola H Abd Elaziz, B. A. Abdel Hady, Ghada Mohamed S Ahmad, Safaa Abo Alfadl Mohamed, A. Elmalah, I. Ahmad, Entesar O Elsaghier, Marwa FM Elsayed, Hala Naguib Mohamed, Marwa Khairy Abd Elwahab, Ahmed Salah
Purpose: This study aimed to uncover if homocysteine (Hcy) adropin balance expressed by homocysteine/adropin ratio (HAR) is related to severity of disease in coronary artery disease (CAD) patients. Materials & Methods: The present cross-sectional study 50 consecutive patients with low/intermediate CAD severity and other 50 patients with severe CAD. Hcy and adropin levels were assessed using commercially available kits. Results: Patients with low/moderate severity CAD expressed significantly lower HAR. According to HAR, all patients were classified into those with low HAR (
{"title":"Relation between homocysteine-to-adropin ratio and severity of coronary artery disease","authors":"Ola H Abd Elaziz, B. A. Abdel Hady, Ghada Mohamed S Ahmad, Safaa Abo Alfadl Mohamed, A. Elmalah, I. Ahmad, Entesar O Elsaghier, Marwa FM Elsayed, Hala Naguib Mohamed, Marwa Khairy Abd Elwahab, Ahmed Salah","doi":"10.29333/ejgm/13964","DOIUrl":"https://doi.org/10.29333/ejgm/13964","url":null,"abstract":"Purpose: This study aimed to uncover if homocysteine (Hcy) adropin balance expressed by homocysteine/adropin ratio (HAR) is related to severity of disease in coronary artery disease (CAD) patients. Materials & Methods: The present cross-sectional study 50 consecutive patients with low/intermediate CAD severity and other 50 patients with severe CAD. Hcy and adropin levels were assessed using commercially available kits. Results: Patients with low/moderate severity CAD expressed significantly lower HAR. According to HAR, all patients were classified into those with low HAR (<median) and high HAR (≥HAR). Comparison between these subgroups revealed that patients with low HAR had significantly lower number of affected vessels and lower SYNTAX score. Also, it was found that HAR is correlated with SYNTAX scores in all patients and in patients with severe CAD. Conclusions: Hcy and adropin levels are interlinked, HAR can effectively distinguish severe from non-severe CAD.","PeriodicalId":44930,"journal":{"name":"Electronic Journal of General Medicine","volume":"70 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139125112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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