Study on the association between total vitamin D levels and diabetic retinopathy in type 2 diabetic mellitus

M. Kuruvila, Sunil Biradar
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Abstract

This study aims to recognize the interrelation among total vitamin D levels and diabetic retinopathy in diabetic mellitus particular type 2 variant.That was a cross-sectional look on 276 patients with diabetes mellitus. Cases were grouped similarly into with and without DR.Screening tactics like unique records, best-corrected visual acuity, fundoscopic examination, and blood investigations like fasting blood sugar, post prandial blood sugar, HbA1C vitamin-D were carried out. Diabetic retinopathy is graded the use of ETDRS.The relation of the period of diabetes to the severity of retinopathy showed an advantageous correlation, with a p-value <0.001. It has confirmed an inverse relationship among the severity of diabetic retinopathy and Vitamin D values. Sufferers with mild NPDR and moderate NPDR had Vitamin D insufficiency, which decreased to Vitamin D deficiency stages in severe NPDR and PDR.A relation change is observed among diabetic retinopathy and total Vitamin D levels. Henceforth, it is important to examine the affiliation of Vitamin D with the extent of DR, its use to forecast of the severity of DR, and as a device to restrict or prevent the development of retinopathy modifications.
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关于 2 型糖尿病患者总维生素 D 水平与糖尿病视网膜病变之间关系的研究
这项研究的目的是认识总维生素 D 水平与糖尿病视网膜病变之间的相互关系,尤其是在糖尿病 2 型变异型患者中。该研究对 276 名糖尿病患者进行了横断面观察,将病例同样分为有糖尿病和无糖尿病两组。进行了独特记录、最佳矫正视力、眼底镜检查以及空腹血糖、餐后血糖、HbA1C 维生素-D 等血液检查等筛查手段。采用 ETDRS 对糖尿病视网膜病变进行分级。糖尿病时期与视网膜病变严重程度的关系显示出良好的相关性,P 值小于 0.001。研究证实,糖尿病视网膜病变的严重程度与维生素 D 值呈反比关系。轻度 NPDR 和中度 NPDR 患者维生素 D 不足,重度 NPDR 和 PDR 患者维生素 D 缺乏。因此,研究维生素 D 与糖尿病视网膜病变程度的关系、利用维生素 D 预测糖尿病视网膜病变的严重程度,以及将维生素 D 作为限制或预防视网膜病变发展的一种手段,具有重要意义。
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