Heba Mohamed, Bassma H. Elwakil, Mohamed A. Hagar, M. Aouad, N. Rezki, Z. Olama, Y. El Kilany, Mohamed A. Zakaria
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引用次数: 0
Abstract
: Drug resistance is a major global problem leading to higher morbidity and mortality rates especially among hospitalized patients. Hence, in the present study, 1,2,3-Triazole-acetophnone molecular conjugates 3a-c were resynthesized and then used in nanoformulated composites ( 3a-cCNPs) using chitosan as a matrix to give nano compounds of particle sizes ranging from 20 to 40 nm. Antimicrobial activity of the synthesized compounds and the nanoformulated analogues against some multi-drug resistant microbes revealed that 3bCNPs was the most potent candidate due to its high efficiency against multi-drug resistant (MDR) microbes that reached complete microbial cells eradication after 4 hours. The synthesized nanoparticles
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