The influence of HDBA organic complex with vitamin D and calcium on the effectiveness of medical rehabilitation of patients with osteoporosis

Abstract

Objective. To study the effect of basic pathogenetic therapy of osteoporosis and nutritional support using HDBA organic complex with vitamin D and calcium on the effectiveness and duration of maintaining the effect of medical rehabilitation, bone mineral density and the incidence of falls in patients with osteoporosis. Material and methods. The study included 119 patients aged 50 to 80 years, admitted to the inpatient stage of medical rehabilitation and diagnosed with osteoporosis according to one of the three diagnostic criteria formulated in the clinical recommendations of the Russian Ministry of Health, which were randomized in 3 groups. Patients in group 1 (n=41) were prescribed pathogenetic antiresorptive therapy for osteoporosis (bisphosphonates or denosumab) for 12 months, depending on the severity and clinical features of osteoporosis, contraindications to various types of therapy and the patient’s preferences regarding the frequency and mode of administration of the drug for the treatment of osteoporosis, in combination with nutritional support of the dietary supplement Osteomed Forte, containing an organic HDBA complex with vitamin D and calcium. Patients in group 2 (n=39) were prescribed only nutritional support with the dietary supplement Osteomed Forte in the same dosage. Patients of the third group made up the comparison group (n=39), in which patients did not receive any interventions. A control examination was carried out after completion of the rehabilitation course – 20 days after inclusion in the study, as well as 6 and 12 months after the start of treatment. Results. Long-term nutritional support of patients with osteoporosis using HDBA organic complex with vitamin D and calcium helps maintain muscle strength values achieved during rehabilitation for up to 6 months, indicators of quality of life and balance for up to 12 months after completion of rehabilitation, as well as significant increase in bone mineral density after 12 months compared to the baseline: in combination with pathogenetic therapy for osteoporosis – by 4.2% in the spine, by 3.0% in the femoral neck and by 2.7% in the proximal femur, without antiresorptive therapy – by 1.8% in the spine. Conclusion. Nutritional support in the form of correction of dietary calcium deficiency and vitamin D deficiency and the prescription of pathogenetic therapy for osteoporosis should be a mandatory part of complex rehabilitation measures in patients with osteoporosis to increase bone mineral density, improve efficiency and long-term maintenance of the results of medical rehabilitation.