CORRELATION OF SERUM LACTATE LEVELS WITH SURVIVAL IN PATIENTS WITH SEPSIS

Abstract

Introduction: Sepsis is defined as a potentially fatal organ dysfunction caused by an unbalanced host response to infection. The primary objective of the study is to correlate serum lactate with the results of sepsis. The secondary objective of the study is to find associations of lactate in serum with the various etiological factors of sepsis and to correlate serum lactate with severity of sepsis. Material and Methods: This prospective cross-sectional study was conducted in Intensive Care Unit (ICU) and EmergencyDepartment (ED) for sepsis in NRI institute of medical sciences. A sixty five patients of both genders were included in the study. The study period were around 18 months from March 2021 to September 2022. Clinical examination and biochemical tests for blood levels of triglycerides, HDL and fasting blood glucose levels were done.Permission from Institutional Ethical Committee(IEC) were obtained. After getting permission from the Institutional Ethical Committee(IEC), information regarding the study were explained to the patients. Written and informed consent was obtained from them. Patients newly started on antidepressant treatment will be selected psychiatric department. Results: In the present study about 69%were in the age of 25 to 50 years. About 28% were in the age of more than 50 years. Only 3% were in the age of less than 25 years.Mean age is 48.87 and standard deviation is 3.21.About 65% were males and 35% were females.About 12% of patients required ventilation. About 77% survived. The relationship between serum lactate levels and outcome is statistically significant (P=<0.05) Conclusion: The fundamental goals of sepsis and septic shock care are early detection and immediate fluid resuscitation.