STREAMLINED SYNTHESIS: ENHANCING THE LEIMGRUBER-BATCHO INDOLE ROUTE FOR ONE-POT TANDEM PRODUCTION OF 2,3-UNSUBSTITUTED INDOLES

Aviraboina Siva Prasad, Talupula Venkateswara Rao
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Abstract

Aim:This study aims to create a new one-pot synthesis method for substituted indoles, focusing on efficiency, by-product reduction, and comparative advantages over conventional Leimgruber-Batcho reactions. Methods:Researchers optimized a one-pot synthesis strategy for maximum yield, reduced by-products, and resource utilization, comparing it to traditional Leimgruber-Batcho reactions, ensuring a sustainable, environmentally friendly approach. Results:The one-pot synthesis method efficiently produced substituted indoles with reduced environmental impact, yielding more than conventional reactions, shortened reaction times, and aligning with green chemistry principles. Conclusions:The one-pot synthesis method for substituted indoles, using 2-nitrotoluenes and dimethylformamide dimethyl acetal, is a significant advancement in the field, offering improved efficiency, environmental sustainability, and higher yields compared to conventional methods, making it a more resource-effective and economically viable option.
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简化合成:改进莱姆格鲁伯-批次吲哚路线,实现 2,3- 未取代吲哚的一锅串联生产
目的:本研究旨在创建一种新的取代吲哚的单锅合成方法,重点关注效率、副产物的减少以及与传统的莱姆格鲁伯-巴乔反应相比的比较优势。方法:研究人员优化了单锅合成策略,使其与传统的莱姆格鲁伯-巴乔反应相比,产量最大化、副产物减少、资源利用率提高,确保了可持续的环保方法。结果:单锅合成法有效地生产了取代吲哚,减少了对环境的影响,收率高于传统反应,缩短了反应时间,符合绿色化学原则。结论:使用 2-硝基甲苯和二甲基甲酰胺二甲基缩醛进行取代吲哚的单锅合成方法是该领域的一大进步,与传统方法相比,该方法具有更高的效率、环境可持续性和更高的产率,是一种更具资源效益和经济可行性的选择。
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