Invasomes: A vesicular carrier for transdermal delivery

Abstract

The transdermal route serves as a crucial pathway for delivering localized or systemic medications. Recognizing the skin's significance as a vital organ, it is imperative to develop effective strategies for drug delivery through this route. Invasomes represent a novel vesicular system that has shown superior transdermal penetration compared to traditional liposomes. Comprising phospholipids, ethanol, and terpene, invasomes exhibit suitable transdermal penetration properties for soft vesicles. These nanovesicles enhance drug permeability into the epidermis while minimizing systemic absorption, thereby confining drug action within the skin subcaste. In comparison to liposomes and ethosomes, invasomes penetrate deeper into the skin. They offer various advantages, including enhancing medication efficacy, improving patient compliance, and enhancing comfort. The ability to access the skin subcaste enhances the effectiveness of invasomes, which exert their effects by fluidizing the bilayer structure of stratum corneum (SC) lipids and disrupting lipid and intracellular protein interactions. These recently discovered vesicles are tailored for use in topical and transdermal drug delivery due to their saturation effect and high deformability, distinguishing them from transferosomes.