Нyperdiploid мultiple мyeloma-cytogenetic and clinical aspects

Abstract

In the current research the attention is focused on the possibilities of identifying a hyperdiploidy myeloma clone (HdMC) by using a triple-color fluorescence “in situ” hybridization (FISH) probe. The cytogenetic results from the bone marrow aspirates of 26 patients with newly diagnosed multiple myeloma admitted in the Hematology Department of our hospital during the period from March to September 2023 have been analyzed. The group consists of 12 female and 14 male patients with an average age of 67 years. A FISH probe for establishing hyperdiploidy myeloma clone was used as well as the most common methods for detecting genetic aberrations affecting the long and short arms of the 1 and 14q32 chromosome rearrangements. According to the results, two subgroups of patients have been established. The first subgroup consists of the patients with positive FISH probes for hyperdiploidy myeloma and/or 14q34 rearrangements and 1q25/1p36, while the second one consists of patients, negative for all the three probes listed above. A comparison between the demographic, laboratory data and the ISS (International Staging System) stage of the two subgroups has been made. The collected data suggests that the use of the triple-color FISH probe, as well as some other factors in the analyzed information, increases the probability of detecting a HdMC by 23%.