Formulation and Evaluation of Topical Delivery Diosgenin Emulgel for Diabetic Wounds

Abstract

A variety of cellular processes work together in a highly coordinated manner to facilitate a complex and dynamic process of wound healing ensuring the efficient restoration of injured tissue. Diosgenin, a plant sterol saponin is primarily found in various plants. The aim of this research was to create an emulgel containing Diosgenin and examine its effects on wound healing in diabetic rats with excision wounds. Histopathological findings further supported the efficacy of the emulgel and results indicate that the application of Diosgenin Emulgel (DE) shows an effective approach for healing of diabetic wounds. The objective of the research stands to explore the possibility of formulation development and wound-healing capabilities of DE. The study evaluated the wound healing effects of the DE in Streptozotocin-induced (STZ) (55 mg/kg) given by intraperitoneal route diabetes and control group. The emulgel was topically applied to assess its effectiveness in promoting wound healing. The application of DE on the rat wounds resulted in a notable wound closure within a 21-day period and significant epithelization was observed with p < 0.001. The study concluded that the formulation demonstrated remarkable effectiveness in promoting the functional recovery of diabetic wounds.