Effectiveness of Ophtascan Screening in Lubumbashi. Pilot Study on Screening for Cancer and Type 2 Diabetes

Désiré Kamba Banza, R. Lukamba, Simon Henry Opio-Emuna, Cilundika Phillippe, Amani Chuma, Jean-Paul Mande Ngoy, Dophra Nkulu Ngoy, A. Mwembo, O. Luboya
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Abstract

Purpose: Screening and early treatment are the best strategy for controlling cancer and type 2 diabetes (T2DM). Based on artificial intelligence, new software Ophtascan allows the early detection of the following cancers: cervix, endometrium, breast, prostate, lung as well as type 2 diabetes, from the image of the eyes. The objectives of this study were to test the reliability of the test in the detection of type 2 diabetes and to present the prevalence of oncological pathologies detected. Methodology: screening was carried out in two stages: a technical test of the program and mass screening at the University Clinics of Lubumbashi and the Sendwe Hospital of Lubumbashi among volunteers from April 2023 to July 2023. Findings: Of the 98 volunteers screened including 32 men and 66 women, the risk of the following cancers was detected by Ophtascan: in men, 12.5%, 28% and 6% respectively for the prostate, lung (pre-cancer) and lung while in women we had 1.5%, 6%, 3%, 4.5% and 3% respectively for cervix (pre-cancer), cervical cancer, endometrial, breast (pre- cancer) and breast. This cancer screening trial was not accompanied by clinical confirmation of detected diseases due high cost and practical problems. T2DM trial was accompanied by lab blood test for confirmation of results. Proved sensitiviy of Ophtascan for T2DM achieved 91% within blind clinical trial and 100% within technical trial, and 72% of screened people did not suspect they had this disease, detected by Ophtascan. Unique Contribution to theory, Policy and Practice: Ophtascan is feasible in our environment and seems to have high reliability for the detection of type 2 diabetes as screening tool. Ophtascan certainly detected most of the targeted cancers, but the low number of cases does not allow solid conclusions to be drawn. The difficulty of validation for all types of cancer mentioned above due to its high cost for patients, we propose to carry out a new pilot research project which will focus on cervical cancer, for which early treatment is possible at a low cost in our environment.
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卢本巴希的 Ophtascan 筛查效果。癌症和 2 型糖尿病筛查试点研究
目的:筛查和早期治疗是控制癌症和 2 型糖尿病(T2DM)的最佳策略。基于人工智能的新型软件 Ophtascan 可以通过眼部图像早期检测出以下癌症:宫颈癌、子宫内膜癌、乳腺癌、前列腺癌、肺癌以及 2 型糖尿病。本研究的目的是测试该测试在检测 2 型糖尿病方面的可靠性,并介绍所检测到的肿瘤病变的发病率。方法:筛查分两个阶段进行:2023 年 4 月至 2023 年 7 月在卢本巴希大学诊所和卢本巴希 Sendwe 医院对志愿者进行程序技术测试和大规模筛查。结果:在接受筛查的包括 32 名男性和 66 名女性在内的 98 名志愿者中,Ophtascan 检测出了以下癌症的风险:在男性中,前列腺癌、肺癌(癌前病变)和肺癌的风险分别为 12.5%、28%和 6%;在女性中,宫颈癌(癌前病变)、宫颈癌、子宫内膜癌、乳腺癌(癌前病变)和乳腺癌的风险分别为 1.5%、6%、3%、4.5%和 3%。由于费用高昂和实际问题,这项癌症筛查试验没有对查出的疾病进行临床确认。T2DM 试验则通过实验室血液检测来确认结果。在盲法临床试验中,Ophtascan 对 T2DM 的灵敏度达到 91%,在技术试验中达到 100%,72% 的受检者不怀疑自己患有 Ophtascan 检测出的这种疾病。对理论、政策和实践的独特贡献:Ophtascan 在我们的环境中是可行的,作为筛查工具,它在检测 2 型糖尿病方面似乎具有很高的可靠性。Ophtascan 的确能检测出大多数目标癌症,但由于病例数量较少,因此无法得出可靠的结论。由于上述所有类型癌症的验证都很困难,因为患者需要支付高昂的费用,因此我们建议开展一个新的试点研究项目,重点关注宫颈癌,因为在我们的环境中,宫颈癌的早期治疗费用很低。
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