Recurrent Implantation Failure from an Immunological Point of View

Soolmaz Habibi, Parisa Mostafaei, Fariba Ramezanali, Elham Amirchaghmaghi
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Abstract

Introduction: Repeated implantation failure (RIF) is one of the main challenges in modern infertility treatments. Although assisted reproductive technology (ART) has undergone a lot of progression over the last recent years, some women still experience implantation failure after several embryo transfers (ET). Disruption of the mother's immunologic tolerance towards the fetus is one of the risk factors that increases the possibility of rejection the semi-allogeneic embryo by the mother’s immune system and causes failure of embryo implantation. Studies have shown that immunomodulatory treatment approaches, if used in a timely and appropriate manner, have promising results in improving pregnancy outcomes and live birth rates in this group of women. This review focuses on changes in the immune system and the use of immunomodulatory treatments in women with recurrent implantation failure. Conclusion: It seems that the appropriate use of immunologic tests and proper immunomodulatory treatments can manage IVF failure after repeated embryo transfers.
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从免疫学角度看复发性植入失败
简介反复植入失败(RIF)是现代不孕症治疗的主要挑战之一。尽管近年来辅助生殖技术(ART)取得了长足的进步,但仍有一些妇女在多次胚胎移植(ET)后出现植入失败。母体对胎儿免疫耐受的破坏是风险因素之一,它增加了半异体胚胎被母体免疫系统排斥的可能性,导致胚胎植入失败。研究表明,免疫调节治疗方法如果能及时、适当地使用,对改善这类妇女的妊娠结局和提高活产率很有帮助。本综述将重点讨论免疫系统的变化以及免疫调节治疗在反复植入失败妇女中的应用。结论看来,适当使用免疫学检测和适当的免疫调节治疗可以控制反复胚胎移植后的试管婴儿失败。
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