The Comparison of Polyethersulfone (PES)/N-Methyl 2-Pyrrolidone (NMP) on the Fabrication of Hollow Fiber Membranes with Commercial Membranes for Applications Hemodialysis

Materials Science Forum Pub Date : 2024-02-22 DOI:10.4028/p-h8yuss

Nada Mustika Maisarah, S. Nurkhamidah, A. Altway, S. Susianto, F. Taufany, Zumatul Atiko Islamiyah Cahyo, Dewi Puspita Sari, Y. Rahmawati

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Abstract

The decrease in kidney function is caused by an increase in creatinine and urea levels in the blood; this is the cause of chronic kidney failure (GGK) in patients. Hemodialysis membrane technology is an alternative treatment for chronic renal failure by separating dissolved components in the blood, such as creatinine and urea, using dialysate fluid by passing through the membrane pores. Therefore, the characteristics of hemodialysis membranes become essential to meet the requirements of a dialyzer. This study aimed to compare the features of the resulting hemodialysis membrane with several commercial membranes. In this study, there were four kinds of commercial membranes used, namely F8HPS, FX80, LO PS 15, and Nipro Elisio 15-H, were compared with membrane products that have variations in the composition of polyethylene (PES) using N-methyl-2-pyrolidone (NMP) solvents are 22.5; 24; and 25%. The membrane manufacturing method uses nonsolvent-induced precipitation (NISP). The resulting hollow fiber membrane is characterized by surface morphology using a scanning electron microscope (SEM), functional groups (FT-IR), and tensile test analysis (DMA). The results showed that the composition of PES/NMP is 25%, close to the characteristics of Nipro Elisio 15-H.

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聚醚砜（PES）/N-甲基-2-吡咯烷酮（NMP）与应用于血液透析的商用膜在制作中空纤维膜方面的比较

血液中肌酐和尿素水平的升高会导致肾功能下降，这是患者慢性肾衰竭（GGK）的原因。血液透析膜技术是治疗慢性肾衰竭的一种替代疗法，它利用透析液通过膜孔分离血液中的肌酐和尿素等溶解成分。因此，血液透析膜的特性对于满足透析器的要求至关重要。本研究旨在比较所制得的血液透析膜与几种商用膜的特性。本研究中使用了四种商用膜，即 F8HPS、FX80、LO PS 15 和 Nipro Elisio 15-H，与使用 N-甲基-2-吡咯烷酮（NMP）溶剂的聚乙烯（PES）成分变化为 22.5%、24% 和 25%的膜产品进行了比较。膜的制造方法采用非溶剂诱导沉淀法（NISP）。利用扫描电子显微镜（SEM）、官能团（傅立叶变换红外光谱）和拉伸试验分析（DMA）对制得的中空纤维膜进行表面形貌表征。结果表明，PES/NMP 的成分为 25%，接近 Nipro Elisio 15-H 的特性。

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Materials Science Forum

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