A Concise Overview on Orodispersible Film along with their Formulation and Characterization Technique’s

Abstract

Orally fast-dissolving medicine delivery techniques are increasingly common at present. Due to the desire for these delivery systems, oro-dispersible film (ODF) was recently introduced for the delivery of medicines via the oral route. Most of drugs are delivering through oral route in the form of tablets, capsules and liquids, because they are simple to make and have a greater level of patient compliance. But these conventional dosage forms have many problems including big size of dosage form, and fear of chocking. Oral rapid disintegrating/oro-dispersible drug delivery systems were created to tackle such issues. Fast dissolving films were invented for the patients who have swallowing issues with conventional/traditional oral solid dosage forms. They also have a quick onset of effect, taking only a few seconds, because the drug is absorbed directly from the injection site to the systemic circulation, avoiding first-pass metabolism. In the preparation of films, polymers, surfactants, flavoring agents, coloring agents, sweetening agents, saliva stimulating agents, drug, and plasticizer are used. The drug incorporated in ODF should have pleasing taste, low molecular weight, high stability, and high aqueous solubility. Solvent and semisolid casting, hot melt extrusion, and rolling techniques are routinely used to prepare ODFs. Thickness, loss on drying, tensile strength, and elongation percentage are commonly assessed for evaluating ODFs, as well as their resistance to tearing, weight variation, folding endurance, pH, swelling property, transparency, disintegration, dissolution rate, and stability. The purpose of this review article is to provide a quick overview of ODF delivery systems.