The Role of Functional Foods and Nutraceuticals in Disease Prevention and Health Promotion

Manisha Sharma, Vidhya C. S., Komal Ojha, Yashwanth B. S., Barinderjit Singh, Soni Gupta, Shivam Kumar Pandey
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Abstract

Functional foods containing bioactive compounds may help prevent chronic conditions and promote wellness beyond basic nutrition. Likewise, dietary nutraceutical supplements show promise for reducing disease risk. This review synthesizes current evidence regarding effects of key functional foods and nutraceuticals on outcomes related to cardiovascular disease, cancer, inflammation, immunity, microbiome health, and integrative markers of metabolic health. We specifically summarize findings from clinical trials and experimental studies on foods (e.g. fatty fish, soy, cocoa, nuts, berries, yogurt) and nutritional supplements (e.g. probiotics, vitamins, omega fatty acids, phytochemicals). Collectively, data supports that achieving optimal intake of certain bioactive functional food components may help reduce morbidity and mortality from highly prevalent chronic illnesses. However, further research should continue investigating mechanisms of action, safe effective dosages, nutrigenomic responses, and strategies to improve consumer selection and adherence. Ultimately nutrition-based lifestyle approaches emphasizing functional foods and nutraceuticals aligned with dietary guidance have potential to significantly impact public health by filling nutritional gaps, regulating disease pathways, and promoting protective responses.
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功能食品和营养保健品在预防疾病和促进健康方面的作用
含有生物活性化合物的功能性食品可帮助预防慢性疾病,促进基本营养之外的健康。同样,膳食营养保健品也有望降低疾病风险。本综述综合了目前有关主要功能食品和营养保健品对心血管疾病、癌症、炎症、免疫、微生物组健康和代谢健康综合指标的影响的证据。我们特别总结了有关食品(如肥鱼、大豆、可可、坚果、浆果、酸奶)和营养补充剂(如益生菌、维生素、欧米茄脂肪酸、植物化学物质)的临床试验和实验研究结果。总体而言,数据支持实现某些生物活性功能食品成分的最佳摄入量可能有助于降低高发慢性疾病的发病率和死亡率。然而,进一步的研究应继续调查作用机制、安全有效剂量、营养基因组反应以及改善消费者选择和坚持食用的策略。最终,以营养为基础的生活方式方法强调与膳食指南相一致的功能食品和营养保健品,通过填补营养空白、调节疾病途径和促进保护性反应,有可能对公众健康产生重大影响。
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