The effect of isotretinoin therapy on the circulatory system

Paula Banderowicz, Agnieszka Roszyk, Natalia Wierzbowska, Michalina Rodak
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Abstract

Isotretinoin is a drug belonging to the group of retinoids, which is mainly used in dermatology. Through its mechanism of action, it leads to a reduction in sebum production, which effectively inhibits the formation of acne. Unfortunately, this drug exhibits numerous side effects. This study aimed to review the literature in terms of clinical cases and articles on the side effects of isotretinoin in the context of the cardiovascular system. It has been proven that isotretinoin can harm the circulatory system, causing changes in the structure of the heart walls, thromboembolic episodes, coronary events and lipid metabolism disorders. Further clinical trials are needed to better understand these side effects.
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异维A酸治疗对循环系统的影响
异维A酸是一种属于维甲酸类的药物,主要用于皮肤科。它的作用机制是减少皮脂分泌,从而有效抑制痤疮的形成。遗憾的是,这种药物有许多副作用。本研究旨在从心血管系统的角度,对有关异维A酸副作用的临床病例和文章进行文献综述。事实证明,异维A酸会损害循环系统,导致心壁结构改变、血栓栓塞发作、冠状动脉事件和脂质代谢紊乱。要更好地了解这些副作用,还需要进一步的临床试验。
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