COVID-19 AS A TRIGGER FOR THE ONSET AND PROGRESSION OF NEURODEGENERATIVE PATHOLOGY PREDOMINANTLY IN ELDERLY AND SENILE POPULATION

А. Л. Арьев, Е. С. Лаптева
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Abstract

Представлен краткий обзор литературы о связи перенесенного COVID-19 и появления или прогрессирования нейродегенеративной патологии. Показаны этиопатогенетические механизмы поражения ЦНС. Проанализирована доказательная база влияния SARS-CoV-2 на ЦНС, что приводит к развитию долгосрочных неврологических заболеваний, включая нейродегенерацию. Сделан вывод о необходимости разработки официальных критериев и методических рекомендаций по мониторированию в особенности пациентов пожилого и старческого возраста на предмет возможного начала или прогрессирования нейродегенеративной патологии. A brief literature review on the association of COVID-19 and the manifestation or progression of neurodegenerative pathology is presented. The etiopathogenetic mechanisms of central nervous system damage are shown. The evidence base of the effect of SARS-CoV-2 on the central nervous system, which leads to the development of long-term neurological diseases, including neurodegeneration, is analyzed. It is concluded that it is necessary to develop official criteria and methodological recommendations for monitoring especially elderly and senile patients for possible onset or progression of neurodegenerative pathology.
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covid-19是老年人和老年群体神经退行性病变发生和发展的诱因之一
本文简要回顾了有关 COVID-19 与神经退行性病变的出现或发展之间关系的文献。说明了中枢神经系统损伤的病因机制。分析了 SARS-CoV-2 对中枢神经系统的影响、导致长期神经系统疾病(包括神经退行性病变)的证据基础。结论是,有必要制定官方标准和方法建议,以监测特别是老年和高龄患者可能出现的神经退行性病变或其进展情况。本文简要回顾了 COVID-19 与神经退行性病变的表现或进展之间的关系。介绍了中枢神经系统损伤的病因机制。分析了 SARS-CoV-2 对中枢神经系统的影响、导致长期神经系统疾病(包括神经退行性病变)发生的证据基础。结论是,有必要制定官方标准和方法建议,以监测特别是老年和高龄患者可能出现的神经退行性病变或其进展情况。
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