A 22-Year-Old Woman with NMDA Receptor Antibody Encephalitis Possibly Triggered by SARS-CoV-2 Infection

Charles Ce Wang
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Abstract

A 22-year-old woman presented to the emergency department (ED) on two occasions with seizures, altered mental status, psychoses, and behavioral changes. Analysis of both serum and cerebrospinal fluid revealed positive anti-NMDA receptor (NMDAR) antibodies, confirming the diagnosis of NMDAR antibody encephalitis. Interestingly, 5-6 weeks before her ED visits, she had experienced a SARS-CoV-2 infection, potentially serving as a triggering factor for her autoimmune encephalitis. This case adds to the limited instances documented in the literature, highlighting the potential link between SARS-CoV-2 infection and the onset of autoimmune encephalitis
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一名 22 岁女性可能因感染 SARS-CoV-2 而引发 NMDA 受体抗体脑炎
一名 22 岁女性因癫痫发作、精神状态改变、精神病和行为改变两次到急诊科就诊。血清和脑脊液分析均显示抗 NMDA 受体(NMDAR)抗体阳性,确诊为 NMDAR 抗体脑炎。有趣的是,在她去急诊室就诊的 5-6 周前,她曾感染过 SARS-CoV-2,这可能是她患自身免疫性脑炎的诱发因素。本病例补充了文献中记载的有限病例,强调了 SARS-CoV-2 感染与自身免疫性脑炎发病之间的潜在联系。
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