Shuang Xu, Xinyuan Li, Qing Hou, Ning Xu, Qingmiao Lu, Sudan Wang, Chunsun Dai
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引用次数: 0
Abstract
Introduction: Unsaturated fatty acids play an essential role in the progression of diabetic nephropathy (DN). Previous studies were mainly focused on the role of individual unsaturated fatty acid. The serum unsaturated fatty acid patterns in patients with DN remains to be determined.
Methods: A total of 135 patients with DN (DN group) and 322 patients with type II diabetes without nephropathy (non-DN group) were included in this study. Clinical data, serum levels of unsaturated fatty acids and other laboratory indicators were collected. Multivariate logistic regression was applied to identify risk factors for serum unsaturated fatty acids level in both groups. Serum unsaturated fatty acids were subjected to factor analysis to identify distinct fatty acid patterns (FAPs). Multivariable logistic regression was employed to assess the risk of DN associated with different serum FAPs. The role of FAPs major components was further validated at the cellular level.
Results: After adjusting for confounders, three types of unsaturated fatty acid including C20:5 (eicosapentaenoic acid, EPA), C22:6 (docosahexaenoic, DHA) and C22:5 n-3 (docosapentaenoic acid, DPA n-3) were significantly associated with DN in the population. The odds ratios (ORs) (95% confidence interval [CI]) of DN were 0.583 (0.374, 0.908), 0.826 (0.716, 0.954) and 0.513 (0.298, 0.883), respectively. Factor analysis revealed five major FAPs, among of which, only FAP2 (enriched with EPA and DHA) exhibited a significant inverse association with DN. In the multivariate-adjusted model, the OR (95% CI) was 0.678 (0.493, 0.933). At the cellular level, DHA and EPA enriched in FAP2 reduced and a combination of which further decreased extracellular matrix production induced by transforming growth factor beta 1 (TGFβ1) in podocytes and tubular cells.
Conclusions: Our findings suggest that FAP2, enriched with DHA and EPA, is associated with a reduced risk of DN. This highlights the potential of targeting FAP2 for the patients with DN.
期刊介绍：
''Kidney Diseases'' aims to provide a platform for Asian and Western research to further and support communication and exchange of knowledge. Review articles cover the most recent clinical and basic science relevant to the entire field of nephrological disorders, including glomerular diseases, acute and chronic kidney injury, tubulo-interstitial disease, hypertension and metabolism-related disorders, end-stage renal disease, and genetic kidney disease. Special articles are prepared by two authors, one from East and one from West, which compare genetics, epidemiology, diagnosis methods, and treatment options of a disease.
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