INVESTIGATION OF THE HEPATOPROTECTIVE POTENTIAL OF FRACTIONS AND PHYTOSOMAL COMPLEXES OF TELFAIRIA OCCIDENTALIS HOOK F LEAF EXTRACTS ON ALCOHOL-INDUCED HEPATOTOXICITY IN RAT MODELS

Q4 Pharmacology, Toxicology and Pharmaceutics INDIAN DRUGS Pub Date : 2024-01-28 DOI:10.53879/id.61.01.14224

Romanus C. Omeh, K. Okolo, M. E. Ugwueze, C. C. Mbah, Anthony A. Atamma, M. A. Momoh, J. Ogbonna, L. O. Ugorji

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Abstract

The aim of this work was to evaluate the hepatoprotective potential of fractions and phytosomal complexes of Telfairia occidentalis leaf extracts on ethanol-induced hepatotoxicity in rat models. Phytosomal complexes of ethanol extract fractions were prepared by the thin film hydration technique. Hepatoprotective activities were evaluated by biochemical assays and histopathological examination of liver sections. Intoxication of animals with pure ethanol significantly (p < 0.05) elevated their liver enzyme titers, whereas co-administration with various extracts and phytosomal complexes reversed the increases. Histopathological findings revealed liver tissue protective effects of the extracts with the phytosomal complexes exhibiting greater effects (p < 0.05). Significant differences at p ≤ 0.05 were observed in the liver indices of animals treated with co-administered ethanol and extract fractions or phytosomes complexes versus the positive control group. T. occidentalis leaf extract formulated as phytosomes, therefore, has good potential of enhancing the hepatoprotective activities of the extract.

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研究西洋接骨木钩叶提取物的馏分和植物体复合物对酒精诱导的大鼠肝毒性模型的保肝潜力

本研究旨在评估西洋接骨木叶提取物馏分和植物体复合物对乙醇诱导的大鼠肝毒性模型的保肝潜力。采用薄膜水合技术制备了乙醇提取物馏分的植物体复合物。通过生化检测和肝脏切片的组织病理学检查来评估其肝保护活性。用纯乙醇使动物中毒后，其肝脏酶滴度明显升高（p < 0.05），而同时服用各种提取物和植物体复合物则可逆转升高。组织病理学研究结果显示，提取物对肝组织有保护作用，其中植物体复合物的作用更大（p < 0.05）。同时服用乙醇和提取物馏分或植物体复合物的动物的肝脏指数与阳性对照组相比，在 p ≤ 0.05 时有显著差异。因此，将西番莲叶提取物配制成植物体具有增强提取物保肝活性的良好潜力。

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INDIAN DRUGS Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

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