PHARMACEUTICO - ANALYTICAL STUDY OF GANDHAKA KALPA

Abstract

Herbo-mineral formulations occupy a significant seat in Ayurvedic pharmaceutics. Nearly 70% of formulations include a combination of one or more metallic/minerals with several herbs which have a supporting role in treat-ing the disease. Gandhaka is a primary substance and a fundamental part of the Ayurvedic laboratory. Gandha-ka, being the first among the Uparasa Varga, plays a vital role in the preparation of Chaturvidha Rasa-Rasayanas; Sagandha Yogas are considered the most productive among all the herbo-mineral preparations and hence can be used for longer duration without any complications. Gandhaka Kalpa1 is a herbo mineral formula-tion explained in Rasayoga Sagara, which includes the bhavana (trituration) of shuddha Gandhaka with Amalaki Swarasa for seven days. The study aims to prepare Gandhaka Kalpa as per the standard manufacturing proce-dure mentioned in classical texts and to analyse the sample for purity and quality by utilising suitable Analytical parameters. Results -The analysis of Gandhaka Kalpa shows an increase in weight after seven days of Bhavana; the Presence of a low amount of moisture content of Gandhaka Kalpa (2.88%) leads to decreased decomposition and enhanced shelf life and therapeutic value. Low Acid insoluble Ash determines the presence of soft adherent dirt and sand particles. Heavy metal tests and microbial analysis showed results within limits, which refers to the samples' safety profile and the drug's stability. Retention factor values in HPTLC confirmed the multi-polarity index of the compounds and a wide range of active principles.