Improvement of HbA1c, Weight and Fatty Liver by Short Treatment of Imeglimin (Twymeeg)

Takafumi Kawata, Hiroshi Bando, Y. Kato, H. Yamashita, Y. Kato, K. Ogura
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Abstract

The patient is a 55-year-old male with type 2 diabetes (T2D). In his 20s, 30s, and 50s, his body weight was 80 kg, 95 kg, and 90 kg, respectively. HbA1c was 10.9% in March 2023, and he was prescribed imeglimin (Twymeeg) as an oral hypoglycemic agent (OHA). HbA1c decreased to 9.3%, 7.2%, and 6.8% within just 3 months. His body weight also decreased from 86 kg to 82 kg during this period. Liver function tests showed improvement between March and May 2023, with AST decreasing from 54 to 24 U/L, ALT from 121 to 28 U/L, and GGT from 45 to 18 U/L, respectively. This suggests an improvement in fatty liver.
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短期服用 Imeglimin (Twymeeg) 可改善 HbA1c、体重和脂肪肝
患者是一名 55 岁的男性,患有 2 型糖尿病(T2D)。在 20 多岁、30 多岁和 50 多岁时,他的体重分别为 80 千克、95 千克和 90 千克。2023 年 3 月,他的 HbA1c 为 10.9%,医生给他开了伊迈格列明(Twymeeg)作为口服降糖药(OHA)。在短短 3 个月内,HbA1c 分别降至 9.3%、7.2% 和 6.8%。在此期间,他的体重也从 86 公斤降至 82 公斤。肝功能检测显示,2023 年 3 月至 5 月期间,他的肝功能有所改善,谷草转氨酶(AST)从 54 U/L降至 24 U/L,谷丙转氨酶(ALT)从 121 U/L降至 28 U/L,谷草转氨酶(GGT)从 45 U/L降至 18 U/L。这表明脂肪肝有所改善。
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