RADIOPHARMACEUTICAL RENAL DOSIMETRY USING SNYDER / CRISTY-ECKERMAN / SEGARS ANTHROPOMORPHIC REPRESENTATIONS

Abstract

Absorbed doses to the kidneys of adult patients are estimated using the Medical Internal Radiation Dosimetry (MIRD) methodology and the anthropomorphic representations of Snyder, Cristy-Eckerman, and Segars. The radiopharmaceuticals 99mTc(DTPA), 99mTc(DMSA) and 99mTc(MAG3) are used to perform renal function studies in adults. The dose results found for these radiopharmaceuticals  and their representations will allow the exploring of their dosimetric impact on each other. The relative difference in total renal dose by using the Snyder/Segars and Cristy-Eckerman/Segars anthropomorphic-representations was 3.6% and 0.3% when using 99mTc(DMSA); 2.9% and 3.0% when using 99mTc(MAG3); 5.0% and 1.5% when using 99mTc(DTPA). Regardless of the radiopharmaceutical selected, the substitution of Segars phantoms for Snyder or Cristy-Eckerman phantoms does not reflect significant changes in the estimated absorbed dose to the kidneys.