Olive oil Ameliorates renal Ischemia-reperfusion-mediated hepatic and renal changes in stressed rats

Noha S. Sobhy, Mona A. Ahmed, Noha N. Lasheen, W. Baher, M. Elsayed
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Abstract

Background: Renal ischemia-reperfusion injury (IRI) does not only affect kidneys, but also affects remote organs especially the liver. Stress may lead to further progression of renal and hepatic insults. This study was planned to explore the efficacy of olive oil (OO) on the assumed renal and hepatic changes of immobilization stress following renal IRI. Methods: Seventy-seven adult male Wistar albino rats were divided into the following five groups; Sham-Operated Control group, Renal Ischemia-Reperfusion group, Stressed Renal Ischemia-Reperfusion group, OO-Supplemented Renal Ischemia-Reperfusion group) and OO-Supplemented Stressed Renal Ischemia-Reperfusion Group (OO+Stressed+IR). All animals were subjected to determination of renal and hepatic biochemical functions and histopathological examination. Results: Renal IR significantly increased plasma creatinine and urea levels. This was associated with significant rise in serum levels of both ALT and AST, total bilirubin together with plasma level of TNF-[Formula: see text], whereas the plasma level of albumin (ALB) was significantly reduced. In addition, histological disruptions of kidneys and livers were observed. Chronic immobilization stress aggravated the effects of renal IR. Also, renal and hepatic morphological changes were more worsened. Whilst, OO supplementation resulted in significant amelioration of renal and hepatic functions. Also, the kidney and liver morphologic lesions were attenuated. Conclusion: Renal IR not only affected the renal functional and structural integrity but also the remote organ, the liver. Chronic immobilization stress rendered the kidney and liver more prone to injury. OO improved renal and hepatic dysfunction and morphological damage mediated by renal IRI, in control rats and in those exposed to chronic stress which can be exerted partially via its antioxidant, anti- inflammatory and nitric oxide (NO) reducing activities.
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橄榄油可改善应激大鼠缺血再灌注介导的肝脏和肾脏变化
背景:肾缺血再灌注损伤(IRI)不仅会影响肾脏,还会影响远处器官,尤其是肝脏。压力可能导致肾脏和肝脏损伤进一步恶化。本研究计划探讨橄榄油(OO)对肾脏 IRI 后固定应激引起的假定肾脏和肝脏变化的疗效。研究方法将 77 只成年雄性 Wistar 白化大鼠分为以下五组:假手术对照组、肾脏缺血再灌注组、应激肾脏缺血再灌注组、OO 补充肾脏缺血再灌注组和 OO 补充应激肾脏缺血再灌注组(OO+应激+IR)。所有动物均接受了肾脏和肝脏生化功能测定及组织病理学检查。结果肾脏 IR 会明显增加血浆肌酐和尿素水平。与此同时,血清中的谷丙转氨酶(ALT)和谷草转氨酶(AST)、总胆红素以及血浆中的 TNF- [计算公式:见正文] 水平也明显升高,而血浆中的白蛋白(ALB)水平则明显降低。此外,还观察到肾脏和肝脏的组织学损伤。慢性固定应激加重了肾脏 IR 的影响。同时,肾脏和肝脏的形态变化也更加恶化。而补充 OO 则可显著改善肾脏和肝脏功能。此外,肾脏和肝脏的形态学病变也有所减轻。结论肾红外不仅影响肾功能和结构的完整性,而且还影响远端器官--肝脏。长期固定应激使肾脏和肝脏更容易受伤。OO 可改善对照组大鼠和暴露于慢性应激的大鼠的肾脏和肝脏功能障碍以及由肾脏 IRI 引起的形态学损伤,这可部分通过其抗氧化、抗炎和一氧化氮(NO)还原活性来实现。
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审稿时长
12 weeks
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