Synthesis and characterization of capsaicin nanoparticles: An attempt to enhance its bioavailability and pharmacological actions

IF 4.7 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-01-01 DOI:10.1515/gps-2023-0206

M. Sher, Ishtiaq Hussain, Farhat Ali Khan, Muhammad Zahoor, Wiaam Mujahid Sher, Muhammad Saqib Khalil, Muhammad Sulaiman, Riaz Ullah, Sumaira Naz, Essam A. Ali

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Abstract

Herein, capsaicin nanoparticles (NPs) were prepared by two different methods, namely, evaporative precipitation of nanosuspension (EPN) and anti-solvent precipitation with a syringe pump (APSP). The nanoparticles of the necessary sizes were obtained after optimizing experimental parameters such as the solvent-to-anti-solvent ratio and stirring speed. They had spherical shapes and an average diameter of 171.29 ± 1.94 and 78.91 ± 0.54 nm when prepared using the EPN and APSP methods, respectively. Differential scanning calorimetry and an X-ray diffractometer showed that the capsaicin crystallinity decreased. FTIR results showed that the NPs were produced with their original configuration and did not result in the synthesis of any additional structures. The NP formulation had a desirable drug content. They surpassed the unprocessed drug in solubility and displayed the desired stability. Capsaicin NP cream showed many folds of enhanced analgesic, anti-inflammatory, and antimicrobial effects compared to unprocessed capsaicin.

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辣椒素纳米颗粒的合成与表征：尝试提高辣椒素的生物利用度和药理作用

本文采用两种不同的方法制备了辣椒素纳米颗粒（NPs），即纳米悬浮液蒸发沉淀法（EPN）和注射泵反溶剂沉淀法（APSP）。通过优化溶剂与反溶剂的比例和搅拌速度等实验参数，制备出了所需尺寸的纳米颗粒。采用 EPN 和 APSP 方法制备的纳米粒子呈球形，平均直径分别为 171.29 ± 1.94 nm 和 78.91 ± 0.54 nm。差示扫描量热法和 X 射线衍射仪显示辣椒素结晶度降低。傅立叶变换红外光谱（FTIR）结果表明，制备的 NPs 具有原始结构，没有合成任何其他结构。NP 配方具有理想的药物含量。它们的溶解度超过了未加工的药物，并显示出理想的稳定性。与未加工的辣椒素相比，辣椒素 NP 霜的镇痛、消炎和抗菌效果增强了数倍。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567

期刊介绍： ACS Applied Electronic Materials is an interdisciplinary journal publishing original research covering all aspects of electronic materials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials science, engineering, optics, physics, and chemistry into important applications of electronic materials. Sample research topics that span the journal's scope are inorganic, organic, ionic and polymeric materials with properties that include conducting, semiconducting, superconducting, insulating, dielectric, magnetic, optoelectronic, piezoelectric, ferroelectric and thermoelectric. Indexed/Abstracted： Web of Science SCIE Scopus CAS INSPEC Portico