Exploring the antimicrobial potential of biogenically synthesized graphene oxide nanoparticles against targeted bacterial and fungal pathogens

IF 3.8 4区工程技术 Q2 CHEMISTRY, MULTIDISCIPLINARY Green Processing and Synthesis Pub Date : 2024-01-01 DOI:10.1515/gps-2023-0130

Anila Ashraf, Muhammad Altaf, Fozia Abasi, Muhammad Shahbaz, Tanveer Hussain, Md. Arshad Ali, J. Seelan, Baber Ali, M. Mahmoud, Steve Harakeh, Muhammad Hamzah Saleem

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Abstract

Graphene oxide (GO) and reduced graphene oxide (rGO) nanoparticles were synthesized using 40 mL of lemon juice extract as a reducing agent. The synthesized nanoparticles were characterized using various analytical techniques, including UV–visible spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, and X-ray diffraction. The results confirmed the successful synthesis of GO and rGO nanoparticles with varied sizes and shapes. The synthesized nanoparticles were tested for their antimicrobial activity against a range of bacterial and fungal strains, including Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Candida albicans, Fusarium oxysporum, and Aspergillus flavus. Multiple concentrations of GO and rGO nanoparticles were tested, and it was observed that 100 µg·mL−1 of both GO and rGO showed the highest inhibitory effect against bacterial and produced zones of inhibition of 17.66 mm, 18.67 mm, and 17.88 for E. coli, S. aureus, K. pneumoniae and 20.33, 22.45, and 21.34 mm for C. albicans, F. oxysporum, and A. flavus. Comparatively, GO performed well as compared to rGO regarding antimicrobial activity. The synthesized nanoparticles exhibited significant antimicrobial activity against various bacterial and fungal strains and have the potential to be developed as novel antimicrobial agents.

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探索生物合成氧化石墨烯纳米粒子对目标细菌和真菌病原体的抗菌潜力

以 40 mL 柠檬汁提取物为还原剂，合成了氧化石墨烯（GO）和还原氧化石墨烯（rGO）纳米粒子。使用多种分析技术对合成的纳米粒子进行了表征，包括紫外可见光谱、扫描电子显微镜、能量色散 X 射线光谱、傅立叶变换红外光谱和 X 射线衍射。结果证实成功合成了不同大小和形状的 GO 和 rGO 纳米粒子。对合成的纳米粒子进行了抗菌活性测试，测试对象包括一系列细菌和真菌菌株，包括大肠杆菌、金黄色葡萄球菌、肺炎克雷伯氏菌、白色念珠菌、氧孢镰刀菌和黄曲霉。对多种浓度的 GO 和 rGO 纳米粒子进行了测试，结果表明，100 µg-mL-1 的 GO 和 rGO 对细菌的抑制效果最高，对大肠杆菌、金黄色葡萄球菌、肺炎克雷伯菌的抑制区分别为 17.66 毫米、18.67 毫米和 17.88 毫米，对白念珠菌、氧孢镰刀菌和黄曲霉的抑制区分别为 20.33 毫米、22.45 毫米和 21.34 毫米。与 rGO 相比，GO 的抗菌活性更好。合成的纳米粒子对各种细菌和真菌菌株具有显著的抗菌活性，有望开发成新型抗菌剂。

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来源期刊

Green Processing and Synthesis CHEMISTRY, MULTIDISCIPLINARY-ENGINEERING, CHEMICAL

CiteScore

6.70

自引率

9.30%

发文量

审稿时长

7 weeks

期刊介绍： Green Processing and Synthesis is a bimonthly, peer-reviewed journal that provides up-to-date research both on fundamental as well as applied aspects of innovative green process development and chemical synthesis, giving an appropriate share to industrial views. The contributions are cutting edge, high-impact, authoritative, and provide both pros and cons of potential technologies. Green Processing and Synthesis provides a platform for scientists and engineers, especially chemists and chemical engineers, but is also open for interdisciplinary research from other areas such as physics, materials science, or catalysis.