A mathematical study of the adrenocorticotropic hormone as a regulator of human gene expression in adrenal glands

A. Manickam, A. Jaison, D. Lakshmi, Ram Singh, C. T. D. Pravina
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Abstract

In this research, we have introduced compartments for asymptomatic and symptomatic individuals, along with reduced susceptibility, as key factors defining our investigation. The study is carried out in diverse scenarios, considering them as crucial for the essential generation number of the model, set at 3.18( r 0 > 1 {r}_{0}\gt 1 ). The persistent reproduction differential method was used to explore the impact of continuous adrenocorticotropic hormone (ACTH) administration on the global gene expression in primary cultures of both fetal and adult adrenal cells. The study also investigates ACTH’s genetic effects on both adult and fetal human adrenal cells. The conclusion of this study is demonstrated through relevant and correct medical applications.
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关于促肾上腺皮质激素作为人类肾上腺基因表达调节剂的数学研究
在这项研究中,我们引入了无症状和有症状个体的分区,以及易感性的降低,作为界定我们研究的关键因素。研究在不同的情景下进行,认为它们对模型的基本代数至关重要,设定为 3.18(r 0 > 1 {r}_{0}\gt 1)。研究采用了持续繁殖差分法来探讨持续给予促肾上腺皮质激素(ACTH)对胎儿和成年肾上腺细胞原代培养物中全局基因表达的影响。该研究还探讨了促肾上腺皮质激素对成人和胎儿人类肾上腺细胞的遗传影响。本研究的结论通过相关的正确医学应用得以证明。
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来源期刊
Computational and Mathematical Biophysics
Computational and Mathematical Biophysics Mathematics-Mathematical Physics
CiteScore
2.50
自引率
0.00%
发文量
8
审稿时长
30 weeks
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