Comparative Histological Study of the Possible Protective Effect of Valsartan Versus Dexamethasone On Cyclophosphamide-Induced Lung Injury in Adult Male Albino Rat
Fatma Elzahraa Abdel Lattif, Dalia Abdel Aziz, Doha Mohamed, G. Genedy
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Abstract
: Introduction: Interstitial lung diseases are groups of chronic lung diseases characterized by inflammation and fibrosis. Aim of work: The present study was performed to evaluate the possible protective effect of valsartan versus dexamethasone on cyclophosphamide-induced lung injury in adult male albino rat. Material and Methods: Thirty male albino Rats were divided into 6 groups; 5 rats each: group I (Control), group II (Cyclophosphamide), group III (Valsartan), group IV (Dexamethasone), group V (Dexamethasone & Cyclophosphamide), and group VI (Valsartan and Cyclophosphamide). Lung specimens were taken on the 6 th day of experiment. Specimens were subjected to histological (Hematoxylin and Eosin, Periodic Acid-Schiff, and Masson's trichrome) and immunohistochemical (Alpha smooth muscle actin, Clsuter
:导言：间质性肺病是一组以炎症和纤维化为特征的慢性肺病。研究目的本研究旨在评估缬沙坦和地塞米松对环磷酰胺诱导的成年雄性白化大鼠肺损伤可能具有的保护作用。材料和方法：将 30 只雄性白化大鼠分为 6 组，每组 5 只：第 I 组（对照组）、第 II 组（环磷酰胺组）、第 III 组（缬沙坦组）、第 IV 组（地塞米松组）、第 V 组（地塞米松和环磷酰胺组）和第 VI 组（缬沙坦和环磷酰胺组）。实验第 6 天采集肺标本。对标本进行组织学（血色素和伊红、周期性酸-Schiff和马森三色）和免疫组化（α平滑肌肌动蛋白、Clsuter-Schiff和马森三色）检查。
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