A Serf-Based Magnetic Scanning Platform for Multiple Cardiovascular Disease Biomarker Detection

Abstract

As cardiovascular diseases (CVDs) are the leading cause of death worldwide, it is of great importance to realize a rapid and sensitive diagnosis. Cardiac troponin I (cTnI), C-reactive protein (CRP), brain-type natriuretic peptide (BNP), and heart fatty acid binding protein (H-FABP) are four significant diagnostic biomarkers for CVD. Multiple CVD biomarker detection with microfluidics, which can increase both the accuracy and speed of early CVD diagnosis, has emerged as a promising alternative to single-marker analysis. This paper presented a novel two-dimensional magnetic field scanning platform for four types of CVD biomarker detection. A high sensitivity with a detection limit of a few pg/mL for all CVD biomarkers was achieved by combining microfluidics with two-dimensional magnetic field scanning. The measurement technique provides a new magnetic methodology for applications in clinical diagnosis.