A double-edged sword: The complex interplay between engineered nanoparticles and platelets

IF 6.1 2区 医学 Q1 ENGINEERING, BIOMEDICAL Bioengineering & Translational Medicine Pub Date : 2024-04-06 DOI:10.1002/btm2.10669
Yathreb Asaad, Danielle Nemcovsky-Amar, Josué Sznitman, Pierre H. Mangin, Netanel Korin
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Abstract

Nanoparticles (NP) play a crucial role in nanomedicine, serving as carriers for localized therapeutics to allow for precise drug delivery to specific disease sites and conditions. When injected systemically, NP can directly interact with various blood cell types, most critically with circulating platelets. Hence, the potential activation/inhibition of platelets following NP exposure must be evaluated a priori due to possible debilitating outcomes. In recent years, various studies have helped resolve the physicochemical parameters that influence platelet-NP interactions, and either emphasize nanoparticles' therapeutic role such as to augment hemostasis or to inhibit thrombus formation, or conversely map their potential undesired side effects upon injection. In the present review, we discuss some of the main effects of several key NP types including polymeric, ceramic, silica, dendrimers and metallic NPs on platelets, with a focus on the physicochemical parameters that can dictate these effects and modulate the therapeutic potential of the NP. Despite the scientific and clinical significance of understanding Platelet-NP interactions, there is a significant knowledge gap in the field and a critical need for further investigation. Moreover, improved guidelines and research methodologies need to be developed and implemented. Our outlook includes the use of biomimetic in vitro models to investigate these complex interactions under both healthy physiological and disease conditions.

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双刃剑:工程纳米粒子与血小板之间复杂的相互作用
纳米粒子(NP)在纳米医学中发挥着至关重要的作用,它是局部治疗药物的载体,可将药物精确输送到特定的疾病部位和病症。在全身注射时,纳米粒子可直接与各种血细胞相互作用,其中最重要的是与循环中的血小板相互作用。因此,必须事先评估接触 NP 后血小板的潜在激活/抑制作用,因为这可能会导致衰弱。近年来,各种研究帮助解决了影响血小板与 NP 相互作用的理化参数,并强调了纳米粒子的治疗作用,如增强止血或抑制血栓形成,或反过来描绘了其注射后的潜在不良副作用。在本综述中,我们讨论了几种主要 NP 类型(包括聚合物、陶瓷、二氧化硅、树枝状聚合物和金属 NP)对血小板的一些主要影响,重点是能决定这些影响并调节 NP 治疗潜力的理化参数。尽管了解血小板-NP 相互作用具有重要的科学和临床意义,但该领域仍存在巨大的知识差距,亟需进一步研究。此外,还需要制定和实施更好的指南和研究方法。我们的展望包括使用仿生体外模型来研究这些在健康生理和疾病条件下的复杂相互作用。
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来源期刊
Bioengineering & Translational Medicine
Bioengineering & Translational Medicine Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
8.40
自引率
4.10%
发文量
150
审稿时长
12 weeks
期刊介绍: Bioengineering & Translational Medicine, an official, peer-reviewed online open-access journal of the American Institute of Chemical Engineers (AIChE) and the Society for Biological Engineering (SBE), focuses on how chemical and biological engineering approaches drive innovative technologies and solutions that impact clinical practice and commercial healthcare products.
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