Ferrocene-Based Antioxidant Self-Healing Hydrogel via the Biginelli Reaction for Wound Healing

IF 5.1 Q1 POLYMER SCIENCE ACS Macro Letters Pub Date : 2024-04-09 DOI:10.1021/acsmacrolett.4c00063

Rui Yuan, Zhao Fang, Fang Liu, Xianzhe He, Sa Du, Nan Zhang, Qiang Zeng, Yen Wei, Yuwei Wu* and Lei Tao*,

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Abstract

The development of antioxidant wound dressings to remove excessive free radicals around wounds is essential for wound healing. In this study, we developed an efficient strategy to prepare antioxidant self-healing hydrogels as wound dressings by combining multicomponent reactions (MCRs) and postpolymerization modification. A polymer containing ferrocene and phenylboronic acid groups was developed via the Biginelli reaction, followed by efficient modification. This polymer is antioxidant due to its ferrocene moieties and can rapidly cross-link poly(vinyl alcohol) to realize an antioxidant self-healing hydrogel through dynamic borate ester linkages. This hydrogel has low cytotoxicity and is biocompatible. In in vivo experiments, this hydrogel is superior to existing clinical dressings in promoting wound healing. This study demonstrates the value of the Biginelli reaction in exploring biomaterials, potentially offering insights into the design of other multifunctional polymers and related materials using different MCRs.

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二茂铁基抗氧化自愈合水凝胶通过比吉内利反应促进伤口愈合

开发抗氧化伤口敷料以清除伤口周围过多的自由基对伤口愈合至关重要。在这项研究中，我们结合多组分反应（MCR）和后聚合改性，开发出一种制备抗氧化自愈合水凝胶伤口敷料的高效策略。通过 Biginelli 反应开发出了一种含有二茂铁和苯硼酸基团的聚合物，随后进行了高效改性。这种聚合物因含有二茂铁而具有抗氧化性，并能通过动态硼酸酯连接快速交联聚（乙烯醇），实现抗氧化自愈合水凝胶。这种水凝胶具有低细胞毒性和生物相容性。在体内实验中，这种水凝胶在促进伤口愈合方面优于现有的临床敷料。这项研究证明了比吉内利反应在探索生物材料方面的价值，有可能为使用不同的 MCR 设计其他多功能聚合物和相关材料提供启示。

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来源期刊

ACS Macro Letters 化学-

CiteScore

10.40

自引率

3.40%

发文量

209

审稿时长

1 months

期刊介绍： ACS Macro Letters publishes research in all areas of contemporary soft matter science in which macromolecules play a key role, including nanotechnology, self-assembly, supramolecular chemistry, biomaterials, energy generation and storage, and renewable/sustainable materials. Submissions to ACS Macro Letters should justify clearly the rapid disclosure of the key elements of the study. The scope of the journal includes high-impact research of broad interest in all areas of polymer science and engineering, including cross-disciplinary research that interfaces with polymer science. With the launch of ACS Macro Letters, all Communications that were formerly published in Macromolecules and Biomacromolecules will be published as Letters in ACS Macro Letters.