Association of advanced glycation end products with ear lobe crease: A cross-sectional study

IF 3 2区医学 Q2 ENDOCRINOLOGY & METABOLISM Journal of Diabetes Pub Date : 2024-04-10 DOI:10.1111/1753-0407.13548

Yuepeng Wang, Yu Xin, Binqi Li, Qingzheng Wu, Ping An, Bing Li, Yijun Li, Li Zang, Weijun Gu, Yiming Mu

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Abstract

Objective

Several studies have demonstrated a significant association between the presence of the ear lobe crease (ELC) and cardiovascular disease. Advanced glycation end-products (AGEs) can affect the structures and functions of proteins and contribute to the development of diabetic complications. However, few studies have reported the relationship between AGEs and ELC. The purpose of this study was to investigate the correlation of skin autofluorescence (SAF)-AGE_age (SAF-AGEs × age/100) with ELC.

Methods

This cross-sectional study enrolled 6500 eligible participants from two communities in Beijing. Skin autofluorescence (SAF) was used to measure skin AGEs (SAF-AGEs). SAF-AGE_age was defined as AGEs × age/100. Binary logistic regression analysis and linear regression analysis nested in logistic models were applied to test outcomes.

Results

The overall prevalence of ELC with an average age of 62.7 years participants was 57.1% (n = 3714). Age, fasting blood glucose, systolic blood pressure, and lipoprotein cholesterol were all greater in participants with ELC. ELC-positive participants had higher prevalence of coronary heart disease. Logistic analysis showed a significantly positive relationship between quartiles of SAF-AGE_age and ELC (odds ratio [OR] 1.526, 95% CI 1.324–1.759; OR 2.072, CI 1.791–2.396; and OR 2.983, CI 2.551–3.489) for the multivariate-adjusted models, respectively. Stratified research revealed that those with a history of diabetes, hypertension, or coronary heart disease experienced the connection between SAF-AGE_age and ELC.

Conclusion

ELC is associated with coronary heart disease, and the SAF-AGE has a potential role in ELC development in elder people.

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高级糖化终产物与耳垂皱褶的关系：横断面研究

目的多项研究表明，耳垂褶皱（ELC）的存在与心血管疾病之间存在显著关联。高级糖化终产物（AGEs）会影响蛋白质的结构和功能，并导致糖尿病并发症的发生。然而，很少有研究报道 AGEs 与 ELC 之间的关系。本研究旨在探讨皮肤自动荧光（SAF）-年龄（SAF-AGEs × 年龄/100）与 ELC 的相关性。方法这项横断面研究从北京的两个社区招募了 6500 名符合条件的参与者。皮肤自发荧光（SAF）用于测量皮肤AGEs（SAF-AGEs），SAF-AGEs定义为AGEs × 年龄/100。采用二元逻辑回归分析和嵌套在逻辑模型中的线性回归分析来检验结果。结果平均年龄为 62.7 岁的参与者的 ELC 患病率为 57.1%（n = 3714）。ELC患者的年龄、空腹血糖、收缩压和脂蛋白胆固醇均较高。ELC 阳性参与者的冠心病发病率更高。逻辑分析表明，在多变量调整模型中，SAF-AGE 年龄四分位数与 ELC 之间存在明显的正相关关系（几率比 [OR] 分别为 1.526，95% CI 1.324-1.759；OR 2.072，CI 1.791-2.396；OR 2.983，CI 2.551-3.489）。分层研究显示，那些有糖尿病、高血压或冠心病病史的人经历了 SAF-AGE 年龄与 ELC 之间的联系。结论 ELC 与冠心病有关，而 SAF-AGE 在老年人 ELC 的发展中具有潜在作用。

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来源期刊

Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

2.20%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Diabetes (JDB) devotes itself to diabetes research, therapeutics, and education. It aims to involve researchers and practitioners in a dialogue between East and West via all aspects of epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. The Editorial team is international with a unique mix of Asian and Western participation. The Editors welcome submissions in form of original research articles, images, novel case reports and correspondence, and will solicit reviews, point-counterpoint, commentaries, editorials, news highlights, and educational content.