{"title":"A pH-Sensitive Smart Monomer Prevents Oral Cancer Progression","authors":"Shiyu Liu, Jing Chen, Xuedong Zhou, Yu Hao, Yawen Zong, Yangyang Shi, Xiao Guo, Qi Han, Mingyun Li, Bolei Li, Lei Cheng","doi":"10.1002/anbr.202470041","DOIUrl":null,"url":null,"abstract":"<p><b>Cancer Treatment</b>\n </p><p>Oral cancer shows an acidic tumor microenvironment. A pH-sensitive tertiary amine monomer dodecylmethylaminoethyl methacrylate (DMAEM) has been designed, which displays reversible protonation and deprotonation reactions according to the pH changes. In the acidic microenvironment DMAEM could be protonated into strong cytotoxic quaternary ammonium monomers - Dimethylaminododecyl methacrylate (DMADDM). By this means, DMAEM inhibits the progression of oral cancer. More details can be found in article number 2300119 by Bolei Li, Lei Cheng, and co-workers.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":29975,"journal":{"name":"Advanced Nanobiomed Research","volume":"4 4","pages":""},"PeriodicalIF":4.0000,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anbr.202470041","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Nanobiomed Research","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/anbr.202470041","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Cancer Treatment
Oral cancer shows an acidic tumor microenvironment. A pH-sensitive tertiary amine monomer dodecylmethylaminoethyl methacrylate (DMAEM) has been designed, which displays reversible protonation and deprotonation reactions according to the pH changes. In the acidic microenvironment DMAEM could be protonated into strong cytotoxic quaternary ammonium monomers - Dimethylaminododecyl methacrylate (DMADDM). By this means, DMAEM inhibits the progression of oral cancer. More details can be found in article number 2300119 by Bolei Li, Lei Cheng, and co-workers.
期刊介绍：
Advanced NanoBiomed Research will provide an Open Access home for cutting-edge nanomedicine, bioengineering and biomaterials research aimed at improving human health. The journal will capture a broad spectrum of research from increasingly multi- and interdisciplinary fields of the traditional areas of biomedicine, bioengineering and health-related materials science as well as precision and personalized medicine, drug delivery, and artificial intelligence-driven health science.
The scope of Advanced NanoBiomed Research will cover the following key subject areas:
▪ Nanomedicine and nanotechnology, with applications in drug and gene delivery, diagnostics, theranostics, photothermal and photodynamic therapy and multimodal imaging.
▪ Biomaterials, including hydrogels, 2D materials, biopolymers, composites, biodegradable materials, biohybrids and biomimetics (such as artificial cells, exosomes and extracellular vesicles), as well as all organic and inorganic materials for biomedical applications.
▪ Biointerfaces, such as anti-microbial surfaces and coatings, as well as interfaces for cellular engineering, immunoengineering and 3D cell culture.
▪ Biofabrication including (bio)inks and technologies, towards generation of functional tissues and organs.
▪ Tissue engineering and regenerative medicine, including scaffolds and scaffold-free approaches, for bone, ligament, muscle, skin, neural, cardiac tissue engineering and tissue vascularization.
▪ Devices for healthcare applications, disease modelling and treatment, such as diagnostics, lab-on-a-chip, organs-on-a-chip, bioMEMS, bioelectronics, wearables, actuators, soft robotics, and intelligent drug delivery systems.
with a strong focus on applications of these fields, from bench-to-bedside, for treatment of all diseases and disorders, such as infectious, autoimmune, cardiovascular and metabolic diseases, neurological disorders and cancer; including pharmacology and toxicology studies.
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