Independent and interactive associations of heart rate and obesity with type 2 diabetes mellites: A population-based study

IF 3 2区医学 Q2 ENDOCRINOLOGY & METABOLISM Journal of Diabetes Pub Date : 2024-04-10 DOI:10.1111/1753-0407.13529

Tianxin Zhu, Qingyu Chen, Hongxing Chen, Lili You, Dan Liu, Xiaoyun Zhang, Feng Li, Hongshi Wu, Juying Tang, Diaozhu Lin, Kan Sun, Li Yan, Meng Ren

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Abstract

Background

Although obesity and heart rate (HR) were closely related to the prevalence and development of type 2 diabetes mllitus (T2DM), few studies have shown a co-association effect of them on T2DM. We aimed at assessing the interactive effects of HR and obesity with prevalence of T2DM in Chinese population, providing the exact cutpoint of the risk threshold for blood glucose with high HR.

Materials and Methods

In the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study (REACTION) cohorts (N = 8398), the relationship between HR and T2DM was explored by linear regression, logistic regression, and restricted cubic spline, and odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Interaction terms between HR and body mass index (BMI) and HR and waist circumference (WC) were introduced into the logistic regression model.

Results

In those with HR > 88.0 beats/min, fasting plasma glucose and oral glucose tolerance tests were significantly correlated with HR, and the prevalence of T2DM was highly correlated with HR (all p < .05). There were interactive associations of HR and obesity in patients with T2DM with HR < 74 beats/min.

Conclusion

High HR was in interaction with obesity, associating with prevalence of T2DM. The newly subdivided risk threshold for HR with T2DM might be HR > 88 beats/minute.

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心率和肥胖与 2 型糖尿病的独立和交互关系：基于人群的研究

背景虽然肥胖和心率（HR）与 2 型糖尿病（T2DM）的发病率和发展密切相关，但很少有研究表明它们对 T2DM 有共同的影响。我们的目的是评估心率和肥胖与中国人群 T2DM 患病率的交互影响，提供高心率血糖风险阈值的确切切点。材料与方法在中国糖尿病患者风险评估：纵向研究（REACTION）队列（N = 8398）中，通过线性回归、逻辑回归和限制性立方样条法探讨了心率与 T2DM 之间的关系，并计算了几率比（ORs）和 95% 置信区间（CIs）。在逻辑回归模型中引入了心率与体重指数（BMI）和心率与腰围（WC）之间的交互项。结果在心率为 88.0 次/分的人群中，空腹血浆葡萄糖和口服葡萄糖耐量试验与心率显著相关，T2DM 的患病率与心率高度相关（所有 p 均为 0.05）。在心率为 74 次/分的 T2DM 患者中，心率与肥胖存在交互关联。结论高心率与肥胖相互影响，与 T2DM 的患病率有关。新细分的 T2DM 患者心率风险阈值可能是心率大于等于 88 次/分。

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来源期刊

Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

2.20%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Diabetes (JDB) devotes itself to diabetes research, therapeutics, and education. It aims to involve researchers and practitioners in a dialogue between East and West via all aspects of epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. The Editorial team is international with a unique mix of Asian and Western participation. The Editors welcome submissions in form of original research articles, images, novel case reports and correspondence, and will solicit reviews, point-counterpoint, commentaries, editorials, news highlights, and educational content.