Heterogeneous crystallization of Chlorzoxazone for modulating the physicochemical properties of crystals

IF 4.1 2区材料科学 Q2 ENGINEERING, CHEMICAL Particuology Pub Date : 2024-04-11 DOI:10.1016/j.partic.2024.03.011

Dhayananth Natarajan, Kalaichelvi Ponnusamy, Radhakrishnan Thota Karunakaran

引用次数: 0

Abstract

The polymer on modulating the crystal's habit is an evolving research in pharmaceutical crystallization. This study demonstrates the crystal habit modification of chlorzoxazone (CHZ) by heterogeneous crystallization (HC) in the binary solvent acetonitrile-ethanol (A-E (1:1)) in the presence of polyvinylpyrrolidine (PVP) at concentrations of 0.50, 0.75, and 1.00 wt%. The A-E (1:1) and PVP in HC experiments influenced to change the shape of crystals from needle to plate shape and reduced the crystal size producing a lower aspect ratio (in the range of 1.5–2.3). In the presence of PVP, the CHZ size distribution is 65–78 μm which tends to enhance the powder flow-ability of CHZ crystals and as the PVP concentration increases, the nucleation rate decreases. The solubility of size-reduced CHZ crystals at different pH is found to be improved by 1.2–1.4 times. Hence, HC is deemed effective in modifying the physicochemical attributes of CHZ.

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氯唑沙宗的异质结晶用于调节晶体的理化性质

调节晶体习性的聚合物是制药结晶领域不断发展的一项研究。本研究展示了氯唑沙宗（CHZ）在二元溶剂乙腈-乙醇（A-E (1:1)）中，在聚乙烯吡咯烷（PVP）浓度为 0.50、0.75 和 1.00 wt% 的情况下，通过异相结晶（HC）改变晶体习性的过程。在 HC 实验中，A-E（1:1）和 PVP 使晶体形状从针状变为板状，并减小了晶体尺寸，降低了长宽比（在 1.5-2.3 之间）。在 PVP 的存在下，CHZ 的尺寸分布为 65-78 μm，这往往会提高 CHZ 晶体的粉末流动性，并且随着 PVP 浓度的增加，成核率会降低。粒度减小的 CHZ 晶体在不同 pH 值下的溶解度提高了 1.2-1.4 倍。因此，HC 被认为能有效改变 CHZ 的物理化学属性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Particuology 工程技术-材料科学：综合

CiteScore

6.70

自引率

2.90%

发文量

1730

审稿时长

32 days

期刊介绍： The word ‘particuology’ was coined to parallel the discipline for the science and technology of particles. Particuology is an interdisciplinary journal that publishes frontier research articles and critical reviews on the discovery, formulation and engineering of particulate materials, processes and systems. It especially welcomes contributions utilising advanced theoretical, modelling and measurement methods to enable the discovery and creation of new particulate materials, and the manufacturing of functional particulate-based products, such as sensors. Papers are handled by Thematic Editors who oversee contributions from specific subject fields. These fields are classified into: Particle Synthesis and Modification; Particle Characterization and Measurement; Granular Systems and Bulk Solids Technology; Fluidization and Particle-Fluid Systems; Aerosols; and Applications of Particle Technology. Key topics concerning the creation and processing of particulates include: -Modelling and simulation of particle formation, collective behaviour of particles and systems for particle production over a broad spectrum of length scales -Mining of experimental data for particle synthesis and surface properties to facilitate the creation of new materials and processes -Particle design and preparation including controlled response and sensing functionalities in formation, delivery systems and biological systems, etc. -Experimental and computational methods for visualization and analysis of particulate system. These topics are broadly relevant to the production of materials, pharmaceuticals and food, and to the conversion of energy resources to fuels and protection of the environment.