Detection of endogenous hormones and its effect on auxiliary medical treatment

IF 10.61 Q3 Biochemistry, Genetics and Molecular Biology Biosensors and Bioelectronics: X Pub Date : 2024-04-06 DOI:10.1016/j.biosx.2024.100477

Jiayu Yu , Qilin Wang , Yinchao Chen , Yizhen Ouyang , Haitao Xu

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Abstract

The detection of endogenous hormones is of great significance for disease diagnosis, treatment guidance, and the development of personalized healthcare. By using biosensors, real-time monitoring and quantitative analysis of endogenous hormone levels can be achieved, providing scientific basis for clinical decision-making. The continuous innovation in this field will bring new breakthroughs in medical diagnosis and treatment, which are expected to accelerate the early detection of diseases and the implementation of personalized treatment plans. In this review, we mainly review the research progress of endogenous hormone biosensors based on different biological recognition elements, namely enzyme-based biosensors, immunobiosensors, aptamer-based biosensors, and molecularly imprinted polymer (MIP) based biosensors. Meanwhile, this paper also analyzes the detection efficiency and clinical application of these biosensors. Finally, we summarize the current challenges and future development directions of the different types of biosensors involved in the discussion.

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检测内源性激素及其对辅助医疗的影响

内源性激素的检测对于疾病诊断、治疗指导和个性化医疗的发展具有重要意义。利用生物传感器可以实现对内源性激素水平的实时监测和定量分析，为临床决策提供科学依据。该领域的不断创新将为医学诊断和治疗带来新的突破，有望加速疾病的早期发现和个性化治疗方案的实施。在这篇综述中，我们主要回顾了基于不同生物识别元件的内源性激素生物传感器的研究进展，即基于酶的生物传感器、免疫生物传感器、基于aptamer的生物传感器和基于分子印迹聚合物（MIP）的生物传感器。同时，本文还分析了这些生物传感器的检测效率和临床应用。最后，我们总结了不同类型生物传感器目前面临的挑战和未来的发展方向。

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来源期刊

Biosensors and Bioelectronics: X Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

4.60

自引率

0.00%

发文量

166

审稿时长

54 days

期刊介绍： Biosensors and Bioelectronics: X, an open-access companion journal of Biosensors and Bioelectronics, boasts a 2020 Impact Factor of 10.61 (Journal Citation Reports, Clarivate Analytics 2021). Offering authors the opportunity to share their innovative work freely and globally, Biosensors and Bioelectronics: X aims to be a timely and permanent source of information. The journal publishes original research papers, review articles, communications, editorial highlights, perspectives, opinions, and commentaries at the intersection of technological advancements and high-impact applications. Manuscripts submitted to Biosensors and Bioelectronics: X are assessed based on originality and innovation in technology development or applications, aligning with the journal's goal to cater to a broad audience interested in this dynamic field.