{"title":"Two new pregnane glycosides from the flower buds of Dregea volubilis","authors":"Xiao-Dong Zhang , Bin Qiu , Jie Yu , Ni-Man Bao","doi":"10.1016/j.phytol.2024.04.006","DOIUrl":null,"url":null,"abstract":"<div><p>Two new pregnane glycosides, drevoluoside R (<strong>1</strong>) and drevoluoside S (<strong>2</strong>), along with one known analogue, degeoside A<sub><em>a</em>1</sub> (<strong>3</strong>), were isolated from the fresh flower buds of <em>Dregea</em>. <em>volubilis.</em> The structures of the new metabolites were established on the basis of detailed spectroscopic analysis. Compounds <strong>1–3</strong> were evaluated for their cytotoxicity against five human cancer cell lines with cisplantin as a positive control.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"61 ","pages":"Pages 149-152"},"PeriodicalIF":1.3000,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Letters","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1874390024000612","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Two new pregnane glycosides, drevoluoside R (1) and drevoluoside S (2), along with one known analogue, degeoside Aa1 (3), were isolated from the fresh flower buds of Dregea. volubilis. The structures of the new metabolites were established on the basis of detailed spectroscopic analysis. Compounds 1–3 were evaluated for their cytotoxicity against five human cancer cell lines with cisplantin as a positive control.
期刊介绍：
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
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