Phytochemistry Letters最新文献

英文中文

Announcements of the Phytochemical Society of Europe 欧洲植物化学学会公告

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters

Pub Date : 2026-02-01 DOI: 10.1016/S1874-3900(26)00019-4

引用次数: 0

GC-MS metabolite profiling and computational ranking of Butea monosperma and their predicted contribution to antimicrobial activity against MRSA Butea单精子的GC-MS代谢物分析和计算排序及其对MRSA抗菌活性的预测贡献

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters

Pub Date : 2026-01-30 DOI: 10.1016/j.phytol.2026.104131

Pramod Kumar Mahish , Shweta Singh , Kaushal Kumar Sahu , Dakeshwar Kumar Verma , Gajanan Ghodake , Ravishankar Chauhan , Shushil Kumar Rai , Shailesh Kumar Jadhav

Multi-drug resistance is a critical global health concern, exacerbated by the overuse of antibiotics, particularly during the current pandemic. Among various drug-resistant bacteria, Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant threat to public health. To combat drug-resistant microbes, the scientific community is exploring various strategies. This study investigates potential bioactive compound from Butea monosperma against MRSA. A total of 27 phytochemicals were identified through GC-MS analysis, of which 20 demonstrated interactions with the cell wall-synthesizing and drug resistance-associated STK1 protein of MRSA. Molecular docking studies using the AutoDock program revealed a maximum docking efficiency of −6.7, with hydrogen, alkyl, pi, and sigma bonds being common interaction types between ligands and the target protein. Further evaluation of selected compounds was conducted using the SwissADME program to assess their physicochemical properties, pharmacokinetics, drug-likeness, medicinal chemistry, and water solubility. Bioavailability radar analysis, the boiled egg model, gastrointestinal absorption, and blood-brain barrier penetration studies, followed by the validation of molecules, confirmed that N-[5-(3-Hydroxy-2-methylpropenyl)-1,3,4,5-tetrahydrobenzo[cd]indol-3-yl]-N-methylacetamide, 5-Methoxy-3,7-dihydroxyflavanone, and Dibutyl phthalate were the most promising molecules against MRSA. Further pharmaceutical investigations are required to assess their potential for drug development.

多药耐药性是一个严重的全球卫生问题，抗生素的过度使用加剧了这一问题，特别是在当前大流行期间。在多种耐药细菌中，耐甲氧西林金黄色葡萄球菌（MRSA）对公众健康构成重大威胁。为了对抗耐药微生物，科学界正在探索各种策略。本研究探讨了Butea单精子中潜在的抗MRSA活性化合物。通过GC-MS分析共鉴定出27种植物化学物质，其中20种与MRSA细胞壁合成和耐药相关STK1蛋白相互作用。使用AutoDock程序进行的分子对接研究显示，最大对接效率为−6.7，其中氢键、烷基键、π键和sigma键是配体与目标蛋白之间常见的相互作用类型。使用SwissADME程序对所选化合物进行进一步评价，以评估其理化性质、药代动力学、药物相似性、药物化学和水溶性。生物利用度雷达分析、水煮蛋模型、胃肠吸收和血脑屏障穿透研究，以及分子验证，证实N-[5-（3-羟基-2-甲基丙烯基）-1,3,4,5-四氢苯并[cd]吲哚-3-基]-N-甲基乙酰胺、5-甲氧基-3,7-二羟基黄酮和邻苯二甲酸二丁酯是最有希望抗MRSA的分子。需要进一步的药物研究来评估它们的药物开发潜力。

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引用次数: 0

Mass spectrometry-guided isolation of naphthalenoid pulvinic acids from the Ectomycorrhizal Fungus Pisolithus arhizus 质谱引导分离外生菌根真菌中萘类pulvinic酸

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters

Pub Date : 2026-01-27 DOI: 10.1016/j.phytol.2026.104123

Armelle T. Tsamo , Pierre Le Pogam , André L. Njouonkou , Jérome Vanheuverzwijn , Panagiotis Tsampanis , Véronique Fontaine , Karine Leblanc , Somia Rharrabti , Pierre Mkounga , Augustin E. Nkengfack , Mehdi A. Beniddir

Pisolithus arhizus is a worldwide distributed ectomycorrhizal fungus used in traditional medicine for wound healing and antimicrobial properties. It is also known for natural dye production, ecological significance, and ectomycorrhizal associations that detoxify polluted soils and support plant growth. In this study, an integrated dereplication strategy combining liquid chromatography-tandem mass spectrometry (LC-MS²) with molecular networking was employed to investigate the phytochemical profile of the dichloromethane-methanol crude extract from the fruiting bodies of Pisolithus arhizus (Sclerodermataceae). The molecular networking analysis revealed distinct clusters of naphthalenoid pulvinic acid derivatives and enabled the rapid targeting, isolation, structure elucidation, and identification of a previously undescribed pisoquinone close analogue, named methylpisoquinone (1), alongside the known norbadione A. The isolated compounds were evaluated for their antimicrobial activities against Staphylococcus aureus, Escherichia coli, Candida albicans, and Mycobacterium bovis BCG. Both compounds were inactive at the tested concentrations.

根瘤菌（Pisolithus arhizus）是一种分布在世界各地的外生菌根真菌，在传统医学中用于伤口愈合和抗菌。它也以天然染料生产，生态意义和外生菌根关联而闻名，这些关联可以解毒污染的土壤并支持植物生长。本研究采用液相色谱-串联质谱（LC-MS2）和分子网络相结合的综合反重复策略，研究了硬皮菇（Pisolithus arhizus）子实体二氯甲烷-甲醇粗提物的植物化学特征。分子网络分析揭示了萘类pulvinic酸衍生物的不同簇，并使先前未描述的pisoquinone接近类似物甲基pisoquinone(1)与已知的去甲巴二酮a一起快速靶向，分离，结构阐明和鉴定。分离的化合物对金黄色葡萄球菌，大肠杆菌，白色念珠菌和牛分枝杆菌BCG的抗菌活性进行了评估。两种化合物在测试浓度下均无活性。

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引用次数: 0

Pesticidal, antibacterial, and cytotoxic alkaloids from Stephania kwangsiensis 王思金娘的杀虫、抗菌和细胞毒性生物碱

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters

Pub Date : 2026-01-27 DOI: 10.1016/j.phytol.2026.104125

Zou Biqun , Zeng Siwen , Nong Yanting , Yang Fanrong , Huang Yucheng , Li Jing , Wang Yafeng , Yang Bingyuan , Liu Zhangbin , Li Guiqin , Li Fangyao , Guo Lunfa , He Ruijie , Huang Yonglin

Four previously undescribed alkaloids designated as kwangsine A (1), sinoacutine-O-pulchine (2), 4-hydroxylpalmatrubine (3), and 4-O-methylcolumbamine (4), together with nine known analogues, were isolated from the tubers of Stephania kwangsiensis. The structures of the new compounds (1–4) were elucidated via comprehensive MS and NMR spectroscopic analysis. Their absolute configurations were determined by comparing experimental and calculated ECD spectra or by DFT calculations. Thirty compounds, including the 13 isolates from this study and 17 previously obtained ones, were assessed for pesticidal, antibacterial, and cytotoxic activities. Bioassay results showed that thaicanine N-oxide (23) exhibited strong pesticidal activity against Diaphorina citri, achieving a corrected mortality rate of over 80 % at a concentration of 50 ppm. (6S,6aS,7R)-sukhodianine α-N-oxide (14) exhibited potent antibacterial activity against Bacillus cereus TKL1–3H with an MIC value of 32 μg/mL. Liriodenine (11) showed cytotoxic activity against MCF-7 cells, with IC₅₀ values of 9.68 ± 0.36 μM.

四种先前未被描述的生物碱分别为：kwangsin A(1)、sinacutine - o -pulchine(2)、4- hydroxypalmatrubine(3)和4- o -methylcolumbamine(4)，以及9种已知的类似物。新化合物（1 ~ 4）的结构通过质谱和核磁共振分析得到。它们的绝对构型是通过比较实验和计算ECD谱或DFT计算来确定的。30个化合物，包括本研究分离的13个化合物和先前获得的17个化合物，被评估了杀虫、抗菌和细胞毒活性。生物测定结果表明，噻氨酸n -氧化物（23）对柑橘地虱具有很强的杀虫活性，在浓度为50 ppm时，校正死亡率可达80% %以上。（6S,6aS,7R）-苏霍迪宁α- n -氧化物（14）对蜡样芽孢杆菌TKL1-3H具有较强的抑菌活性，MIC值为32 μg/mL。Liriodenine（11）对MCF-7细胞具有细胞毒活性，IC50值为9.68 ± 0.36 μM。

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引用次数: 0

Two new aromatic meroterpenoids from the fruiting bodies of Ganoderma calidophilum 从芝灵芝子实体中分离出的两个新的芳香萜类化合物

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters

Pub Date : 2026-01-22 DOI: 10.1016/j.phytol.2026.104122

Wei Liu , Li Yang , Qing-Yun Ma , Qing-Yi Xie , Jiao-Cen Guo , Hao-Fu Dai , Yan Hua , You-Xing Zhao

A chemical investigation on the fruiting bodies of Ganoderma calidophilum led to the isolation of two new aromatic meroterpenoids, ganocalidoaroid A (1) and ganocalidoaroid B (2), along with six known compounds. Their planar structures were unequivocally established through comprehensive spectroscopic analysis, including 1D/2D NMR and HRESIMS. The absolute configuration of compound 1 was determined by quantum chemical ECD calculations. In anti-inflammatory activity screening, compound 3 exhibited moderate inhibition of LPS-induced nitric oxide (NO) production in RAW264.7 macrophages with an IC₅₀ value of 50.60 ± 1.19 μmol/L, suggesting its potential as an anti-inflammatory agent.

通过对灵芝子实体的化学研究，分离出两种新的芳香萜类化合物：灵芝碱类化合物A(1)和灵芝碱类化合物B(2)，以及六种已知化合物。通过全面的光谱分析，包括1D/2D NMR和HRESIMS，明确了它们的平面结构。化合物1的绝对构型由量子化学ECD计算确定。在抗炎活性筛选中，化合物3对lps诱导的RAW264.7巨噬细胞产生一氧化氮（NO）具有中等抑制作用，IC50值为50.60 ± 1.19 μmol/L，提示其具有抗炎潜力。

引用次数: 0

New oxepin derivatives from Bauhinia saccocalyx stem bark and their tyrosinase inhibitory and antioxidant activities 从紫荆茎皮中提取新的奥塞平衍生物及其酪氨酸酶抑制和抗氧化活性

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters

Pub Date : 2026-01-21 DOI: 10.1016/j.phytol.2026.104124

Supachai Jadsadajerm, Sutarin Preepram, Natchaya Sawatdirak, Awat Wisetsai

The chemical investigation of the stem bark of Bauhinia saccocalyx led to the isolation of four oxepin derivatives, including two previously undescribed compounds, saccoxepins D (1) and E (2), together with the known saccoxepin A (3) and bauhinoxepin A (4). The structures of these compounds were elucidated by comprehensive spectroscopic analyses, including NMR and HR-MS data. The biological evaluation revealed that saccoxepin E (2) exhibited potent tyrosinase inhibitory activity. In addition, saccoxepin D (1) and saccoxepin A (3) displayed significant antioxidant effects in the DPPH assay. These findings highlight B. saccocalyx stem bark as a promising source of bioactive oxepin derivatives and provide new insights into its phytochemical and bioactive potential.

通过对紫荆菊茎皮的化学研究，分离得到4个oxepin衍生物，包括两个先前未描述的化合物saccoxepins D(1)和E(2)，以及已知的saccoxepin A(3)和bauhinoxepin A(4)。这些化合物的结构通过NMR和HR-MS数据进行了全面的光谱分析。生物学评价表明saccoxepin E(2)具有较强的酪氨酸酶抑制活性。此外，saccoxepin D(1)和saccoxepin A(3)在DPPH实验中显示出显著的抗氧化作用。这些研究结果突出表明，多糖茎皮是一种具有生物活性的奥塞平衍生物，并为其植物化学和生物活性潜力提供了新的见解。

引用次数: 0

Three new pregnane alkaloids from Sarcococca hookeriana 三种新产的麻豆妊娠烷生物碱

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters

Pub Date : 2026-01-20 DOI: 10.1016/j.phytol.2026.104117

Li-xia Zhang , Xiao-hui Sun , Gang Ke , Fang-you Chen , Ya-mei Zhang , Pu-zhao Zhang

Three new pregnane alkaloids, 3β,20α-bis(dimethylamino)pregn-4,6-diene (1), 20(S)-20-hydroxy-3β-N,N-dimethylamino-pregn-4,6-diene-16-one (2), 3β-senecioylamnino-20α-N,N-dimethylamino-6α-hydroxy-pregn-4-ene (3), was isolated from Sarcococca hookeriana. The chemical structures of 1–3 were elucidated following analysis of spectral data. Compound 1 demonstrated cytotoxic effect against human glioblastoma U251 cells with IC₅₀ value of 7.28 μM with temozolomideused as a positive control (IC₅₀ = 220 μM).

从虎角麻中分离得到3个新的孕烷生物碱，3β，20α-双（二甲氨基）孕烷-4,6-二烯(1),20(S)-20-羟基-3β- n， n-二甲氨基-孕烷-4,6-二烯-16- 1 (2),3β- senecioylamino -20α- n， n-二甲氨基-6α-羟基孕烷-4-烯(3)。通过对光谱数据的分析，确定了其中1-3的化学结构。化合物1对人胶质母细胞瘤U251细胞具有细胞毒作用，IC50值为7.28 μM，阳性对照为替莫唑胺（IC50 = 220 μM）。

引用次数: 0

Structural diversity and cytotoxic secondary metabolites from the endophytic fungus Chaetomium globosum 内生真菌毛囊的结构多样性和细胞毒性次生代谢物

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters

Pub Date : 2026-01-19 DOI: 10.1016/j.phytol.2026.104119

Yizhou Bian , Sulu Qin , Shan Ran , Tao Zhu , Haiyan Fu , Wenjing Wang , Xiaolong Yang

Chemical investigation of the endophytic fungus Chaetomium globosum yielded two undescribed compounds: biscognin C (1), identified as a methyl-migrated analogue of biscognin B, and a rare ethyl-substituted dihydropyran derivative (2), together with seven known compounds (3−9). Their structures were unambiguously established through NMR, UV, HRESIMS, and ECD analysis. Compound 1 represents the first reported methyl-migrated biscognin analog, while compound 2 possesses an ethyl substitution distinct from dihydrodehydroacetic acid. Notably, the known compound 3 exhibited potent cytotoxicity against triple-negative breast cancer cells (MDA-MB-231) with an IC₅₀ value of 1.64 μM. These findings expand the structural diversity of fungal secondary metabolites and highlight their potential as anticancer agents.

对内生真菌毛藻的化学研究得到了两种未描述的化合物：biscognin C(1)，鉴定为biscognin B的甲基迁移类似物，一种罕见的乙基取代双氢吡喃衍生物(2)，以及7种已知化合物（3−9）。通过NMR、UV、hresms和ECD分析明确了它们的结构。化合物1是首次报道的甲基迁移的铋素类似物，而化合物2具有不同于二氢脱氢乙酸的乙基取代。值得注意的是，已知化合物3对三阴性乳腺癌细胞（MDA-MB-231）表现出强大的细胞毒性，IC50值为1.64 μM。这些发现扩大了真菌次生代谢物的结构多样性，并突出了它们作为抗癌药物的潜力。

引用次数: 0

Fusariacumines AC, indole alkaloids from Fusarium acuminatum J207-2 with antibacterial activity 镰刀菌J207-2中具有抗菌活性的吲哚类生物碱

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters

Pub Date : 2026-01-19 DOI: 10.1016/j.phytol.2026.104120

Hua Guo , Quan-Ping Diao , Tao Feng , Juan He

In order to search for antibacterial agents against kiwi plant pathogen Pseudomonas syringae pv. actinidiae (Psa), a Gram-negative bacterium that causes kiwi bacterial canker, three new indole alkaloids, fusariacumines A–C (1–3), together with two known ones (5 and 6) have been isolated from a kiwi plant-associated fungus Fusarium acuminatum J207–2. Their chemical structures were determined by spectroscopic methods (1D, 2D NMR and HRESIMS). Compounds 1 and 3–5 exhibited moderate anti-Psa activity with minimum inhibitory concentration (MIC) values ranging from 32 to 128 μg/mL.

为了寻找抗猕猴桃植物病原菌丁香假单胞菌的抗菌药物。从猕猴桃植物相关真菌镰刀菌J207-2中分离到三种新的吲哚类生物碱，镰刀菌a - c（1-3）和两种已知的生物碱（5和6）。通过光谱方法（一维、二维核磁共振和hresms）测定了它们的化学结构。化合物1和3-5具有中等的抗psa活性，最小抑制浓度（MIC）为32 ~ 128 μg/mL。

引用次数: 0

Two new menthane monoterpene derivatives isolated from Hypericum monogynum 从金丝桃中分离的两个新的甲烷单萜衍生物

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters

Pub Date : 2026-01-19 DOI: 10.1016/j.phytol.2026.104121

Yan-Rong Zeng , Hong-Jin Ban , Jing-Yi Yin , Zhan Feng , Ya-Nan Li , Yan Liu , Xiao-Jiang Hao , Chun-Mao Yuan

Eight compounds, including two new menthane monoterpene derivatives (1 and 2) and six known polycyclic polyprenylated acylphloroglucinols (PPAPs, 3–8), were isolated from Hypericum monogynum. The structures of the undescribed compounds were elucidated through comprehensive spectroscopic analysis. Additionally, the cytotoxic effects of the isolated compounds on two drug-resistant cancer cell lines (HepG2/ADR and MCF-7/ADR) were evaluated by the MTT assay. Six PPAPs (3–8) displayed good inhibitory activities against HepG2/ADR and MCF-7/ADR cells, with IC₅₀ values of 3.67–22.34 μM.

从金丝桃中分离到了8个化合物，包括2个新的甲烷单萜衍生物（1和2）和6个已知的多环聚丙烯酰化酰基间苯三酚（PPAPs, 3-8）。通过综合光谱分析对所描述化合物的结构进行了鉴定。此外，通过MTT法评估分离化合物对两种耐药癌细胞株（HepG2/ADR和MCF-7/ADR）的细胞毒作用。6种PPAPs（3 ~ 8）对HepG2/ADR和MCF-7/ADR细胞表现出良好的抑制活性，IC50值为3.67 ~ 22.34 μM。

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全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

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