Inside Front Cover: Cerebrospinal fluid efflux through dynamic paracellular pores on venules as a missing piece of the brain drainage system (EXP2 2/2024)

Abstract

While asleep, the cerebrospinal fluid (CSF) flush over the brain parenchyma via pathways generated by neuroglia cells. The interstitial fluid (ISF) solutes containing metabolic wastes/toxins such as Aβ are collected in the paravenous space, where the CSF-ISF fluid eventually exit into blood through dynamically assembled, trumpet-shaped pores formed by vascular endothelial cells.