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Front Cover: Direct synthesis of high quantum yield lead-free CsCu2I3 powder in water and its application in yellow LED (EXP2 1/2025)
Pub Date : 2025-02-27 DOI: 10.1002/EXP.70013
Heng Guo, Linlin Shi, Zengliang Shi, Yue He, Yizhi Zhu

A phosphor-converted yellow light-emitting diodes (pc-LEDs) device has been produced by coating a low-dimensional CsCu2I3 phosphor with high quantum yield and good stability on a 310 nm ultraviolet chip. The LED device with the as-synthesized phosphor emits a pure, bright yellow color at a current of 20 mA. It shows promising exciting potential applications in photoluminescence and phototherapy fields.

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引用次数: 0
Back Cover: Jellyfish stings-induced cardiac failure was ameliorated through AAG-mediated glycogen-driven ATP production (EXP2 1/2025)
Pub Date : 2025-02-27 DOI: 10.1002/EXP.70014
Zhen Qin, Jinhong Chen, Fang Liu, Bingbing Li, Chenchen Zhang, Xiuxiu Wang, Lin Liu, Mingke Wang, Tingfang Wang, Su Wang, Feifei Yu, Shifeng Wang, Jishun Yang

Jellyfish stings have become a common injury among fishermen and divers. Severe jellyfish stings could worsen cardiac function and even cause cardiac complications, ultimately leading to cardiac failure (CF). Jellyfish stings-induced CF was ameliorated through AAG-mediated glycogen-driven ATP production, promoting glycolytic/mitochondrial metabolic switches to rely energetically primarily on glycolysis, which might serve as a therapeutic target of CF.

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引用次数: 0
Back Cover: High-yield upcycling of feather wastes into solid-state ultra-long phosphorescence carbon dots for advanced anticounterfeiting and information encryption (EXP2 6/2024) 封底:将羽毛废料高产升级再利用为固态超长磷光碳点,用于先进的防伪和信息加密(EXP2 6/2024)
Pub Date : 2024-12-18 DOI: 10.1002/EXP.20240602
Dongzhi Chen, Xin Guo, Xuening Sun, Xiang Feng, Kailong Chen, Jinfeng Zhang, Zece Zhu, Xiaofang Zhang, Xin Liu, Min Liu, Li Li, Weilin Xu

This work presents a high-yield approach to recycle duck feather into carbon dots (CDs) via hydrothermal treatment. The resultant CDs exhibit matrix-free solid-state fluorescence under ultraviolet lamp, and long-lived green room-temperature phosphorescence after removing ultraviolet lamp. Furthermore, their ink demonstrates excellent potential in anticounterfeiting and information encryption, offering a distinctive perspective to reclamation of the feather wastes for environmental sustainability.

本研究提出了一种通过水热处理将鸭毛回收为碳点(CD)的高产方法。所制得的碳点在紫外灯下可发出无基质固态荧光,移除紫外灯后可在室温下发出长寿命绿色磷光。此外,它们的墨水在防伪和信息加密方面具有卓越的潜力,为回收羽毛废料以实现环境可持续发展提供了一个独特的视角。
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引用次数: 0
Frontispiece: Advancements and challenges in brain cancer therapeutics (EXP2 6/2024) 前言:脑癌疗法的进展与挑战(EXP2 6/2024)
Pub Date : 2024-12-18 DOI: 10.1002/EXP.20240603
Fan Bai, Yueyang Deng, Long Li, Ming Lv, Jamoliddin Razzokov, Qingnan Xu, Zhen Xu, Zhaowei Chen, Guojun Chen, Zhitong Chen

This review offers a comprehensive look at brain tumor treatments, including both physical (radiotherapy, ablation, photodynamic therapy, cold plasma) and non-physical approaches (surgery, chemotherapy, immunotherapy). It discusses mechanisms, side effects, and recent advances, stressing the importance of personalized, multi-modal strategies. Balancing efficacy with patient safety is critical, considering the brain's delicate nature and functional preservation needs

这篇综述全面介绍了脑肿瘤的治疗方法,包括物理疗法(放疗、消融、光动力疗法、冷等离子体疗法)和非物理疗法(手术、化疗、免疫疗法)。它讨论了治疗机制、副作用和最新进展,强调了个性化、多模式策略的重要性。考虑到大脑的微妙性质和功能保护需求,平衡疗效与患者安全至关重要。
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引用次数: 0
Front Cover: Piezoelectric stimulation enhances bone regeneration in alveolar bone defects through metabolic reprogramming of macrophages (EXP2 6/2024) 封面:压电刺激通过巨噬细胞的代谢重编程增强牙槽骨缺损的骨再生(EXP2 6/2024)
Pub Date : 2024-12-18 DOI: 10.1002/EXP.20240601
Baiyan Sui, Tingting Ding, Xingyi Wan, Yuxiao Chen, Xiaodi Zhang, Yuanbo Cui, Jie Pan, Linlin Li, Xin Liu

Liu et al. developed a wireless piezoelectric hydrogel with BaTiO3 nanoparticles, generating piezoelectric potentials to reprogram macrophages towards the M2 phenotype, enhancing osteogenesis in bone marrow stem cells and promoting bone regeneration at load-bearing alveolar sites. This piezoelectric-driven osteoimmunomodulation offers new insights for designing next-generation bioactive materials with combined osteoinductive, immunomodulatory, and piezoelectric properties.

Liu 等人开发了一种含有 BaTiO3 纳米颗粒的无线压电水凝胶,其产生的压电势能可将巨噬细胞重编程为 M2 表型,从而增强骨髓干细胞的成骨能力,促进承重牙槽部位的骨再生。这种压电驱动的骨免疫调节为设计兼具诱导骨生成、免疫调节和压电特性的下一代生物活性材料提供了新的思路。
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引用次数: 0
Pioneering Exploration for a lasting and sustainable future 开拓开拓,创造持久和可持续的未来
Pub Date : 2024-12-10 DOI: 10.1002/EXP.20240397
Gaopeng Li, Zhi-Gang Chen, Chengliang Wang
<p>To address the growing global imperative for a sustainable future, the United Nations (UN) adopted the 2030 Agenda for Sustainable Development with 17 sustainable development goals (SDGs) at the 2015 UN Sustainable Development Summit. The agenda encompasses 17 SDGs, which span critical areas such as life, water, energy, climate, hunger, poverty, justice, peace, good health, high-quality education, decent work and economic growth, science and technology. In 2021, <i>Exploration</i>, an international, cross-disciplinary journal, was launched to contribute to these efforts, aiming to inspire and support actionable steps toward a more sustainable future.</p><p>In a broad sense, all publications in <i>Exploration</i> can be viewed as contributions by researchers and scientists toward a more sustainable world. These contributions encompass: (1) water/salt separation for clean water<sup>[</sup><span><sup>1</sup></span><sup>]</sup>; (2) treatment of obsolete water and degradation of plastics for good sanitation; (3) wearable/implantable electronic devices for biomedical applications and good health<sup>[</sup><span><sup>2</sup></span><sup>]</sup>; (4) biotechnology and pharmacology for good health,<sup>[</sup><span><sup>3</sup></span><sup>]</sup> for example, advanced biomedical materials for disease diagnosis or therapy and progresses in drug delivery and tumor therapy; (5) energy conversion technologies as actions to achieve affordable and clean energy and reduce the carbon emission,<sup>[</sup><span><sup>4</sup></span><sup>]</sup> such as CO<sub>2</sub> reduction technologies to convert CO<sub>2</sub> into organic fuels through electrocatalysis or photocatalysis, hydrogen production from water through electrocatalysis and utilization of solar energy by solar cells or photocatalysis based on perovskites, inverted perovskites, and organics; (6) advanced energy storage technologies with high energy density and long cycle lifespan<sup>[</sup><span><sup>5</sup></span><sup>]</sup> to better harness clean and renewable energies, mitigate the climate change, and make the energy storage devices more convenient and portable.</p><p>We firmly believe that sustainable development is essential for the future of humanity. All scientific and technological advancements that contribute to sustainability fall within the scope of this journal and are, therefore, highly encouraged. Beyond the abovementioned cutting-edge research, we welcome studies in agriculture, electronics, photonics, energies, manufacturing, material science, physical science, environmental science, life science, information science, space science, artificial intelligence, and other fields dedicated to enhancing the quality of life and minimizing humanity's environmental impact. Additionally, topics such as the policies, regulations, and initiatives addressing hunger, poverty, conflicts, and inequalities, aligned with the 17 SDGs, are within our field. Our vision for <i>Exploration</i> is to serve
为应对全球对可持续未来日益迫切的需求,联合国在2015年联合国可持续发展峰会上通过了《2030年可持续发展议程》,其中包括17项可持续发展目标。议程包括17项可持续发展目标,涵盖生命、水、能源、气候、饥饿、贫困、正义、和平、良好健康、高质量教育、体面工作和经济增长、科学和技术等关键领域。2021年,国际跨学科期刊《探索》(Exploration)成立,为这些努力做出贡献,旨在激励和支持实现更可持续未来的可行步骤。从广义上讲,《探索》杂志上的所有出版物都可以被视为研究人员和科学家对一个更可持续的世界的贡献。这些贡献包括:(1)净水[1]的水/盐分离;(2)处理废水和降解塑料以保持良好卫生;(3)用于生物医学和健康的可穿戴/植入式电子设备;(4)用于健康的生物技术和药理学,例如用于疾病诊断或治疗的先进生物医学材料以及药物输送和肿瘤治疗方面的进展;(5)能源转换技术作为实现经济实惠的清洁能源和减少碳排放的行动,[4]如二氧化碳减排技术,通过电催化或光催化将二氧化碳转化为有机燃料,通过电催化从水中制氢,利用太阳能电池或基于钙钛矿、倒钙钛矿和有机物的光催化;(6)高能量密度和长循环寿命的先进储能技术,以更好地利用清洁和可再生能源,减缓气候变化,使储能设备更加方便和便携。我们坚信,可持续发展对人类的未来至关重要。所有有助于可持续发展的科学和技术进步都在本刊的范围内,因此受到高度鼓励。除上述前沿研究外,我们欢迎农业、电子、光子学、能源、制造业、材料科学、物理科学、环境科学、生命科学、信息科学、空间科学、人工智能等领域的研究,致力于提高生活质量,减少人类对环境的影响。此外,与17项可持续发展目标相一致的解决饥饿、贫困、冲突和不平等问题的政策、法规和倡议等主题也属于我们的研究领域。我们对探索的愿景是作为一个平台,为各种学科的高质量出版物提供服务,激励研究人员终身致力于探索通往可持续未来的途径。
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引用次数: 0
Inside Front Cover: Conducting polymer hydrogels based on supramolecular strategies for wearable sensors (EXP2 5/2024) 封面内页:基于超分子策略的导电聚合物水凝胶用于可穿戴传感器(EXP2 5/2024)
Pub Date : 2024-10-20 DOI: 10.1002/EXP.20240502
Zhiyuan Sun, Qingdong Ou, Chao Dong, Jinsheng Zhou, Huiyuan Hu, Chong Li, Zhandong Huang

This cover showcases typical supramolecular strategies for developing high-performance conductive polymer hydrogels, providing a comprehensive review of their applications in the field of wearable sensors.

本封面展示了开发高性能导电聚合物水凝胶的典型超分子策略,全面回顾了它们在可穿戴传感器领域的应用。
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引用次数: 0
Front Cover: Neural interfaces: Bridging the brain to the world beyond healthcare (EXP2 5/2024) 封面:神经接口:连接大脑与医疗保健以外的世界(EXP2 5/2024)
Pub Date : 2024-10-20 DOI: 10.1002/EXP.20240501
Shumao Xu, Yang Liu, Hyunjin Lee, Weidong Li

This perspective explores diverse neural interfaces in the brain, offering transformative possibilities for engaging with our environment and enhancing communication. Emphasis is placed on the role of both non-invasive and invasive neural interfaces in transforming practical applications beyond the realm of healthcare, emphasizing the profound implications for remote control, mind connectivity, and integrated urban design.

这一视角探讨了大脑中的各种神经接口,为我们与环境接触和加强交流提供了变革性的可能性。重点放在非侵入式和侵入式神经接口在改变医疗保健领域以外的实际应用中的作用,强调其对远程控制、思维连接和综合城市设计的深远影响。
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引用次数: 0
Back Cover: Detection of biological loads in sewage using the automated robot-driven photoelectrochemical biosensing platform (EXP2 5/2024) 封底:利用自动机器人驱动的光电化学生物传感平台检测污水中的生物负荷(EXP2 5/2024)
Pub Date : 2024-10-20 DOI: 10.1002/EXP.20240504
Yiming Zhang, Zhi Chen, Songrui Wei, Yujun Zhang, Hai Fu, Han Zhang, Defa Li, Zhongjian Xie

The brief description of the cover: Sun Wukong can see throught the monster with his golden eyes. The automated robot-driven photoelectrochemical biosensing platform that harnesses the power of the CRISPR/Cas12a system, much like the golden eyes of Sun Wukong, enables fast, ultra-sensitive, and highly specific monitoring of biological loads in sewage, leaving no hiding place for pathogens. This platform provides crucial data support for early warning, prevention, and control of infectious diseases.

封面简介孙悟空的金睛火眼能看穿妖怪。自动机器人驱动的光电化学生物传感平台利用 CRISPR/Cas12a 系统的强大功能,就像孙悟空的金睛火眼一样,能够快速、超灵敏、高特异性地监测污水中的生物负荷,让病原体无处藏身。这一平台为传染病的早期预警、预防和控制提供了重要的数据支持。
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引用次数: 0
Inside Back Cover: Impact of diabetes mellitus on tuberculosis prevention, diagnosis, and treatment from an immunologic perspective (EXP2 5/2024) 封底内页:从免疫学角度看糖尿病对结核病预防、诊断和治疗的影响(EXP2 5/2024)
Pub Date : 2024-10-20 DOI: 10.1002/EXP.20240503
Zhaoyang Ye, Linsheng Li, Ling Yang, Li Zhuang, Ashok Aspatwar, Liang Wang, Wenping Gong

On the cover: The cover image simulates an ancient Chinese battlefield. It cleverly depicts the struggle between the body's immune cells, Mycobacterium tuberculosis and diabetes. The immune cells and Mycobacterium tuberculosis fight each other, killing and injuring both sides. However, diabetes also launches a sustained attack on the immune cells, resulting in a heavy toll on them. The cover picture was created by Wenping Gong and Zhaoyang Ye.

在封面上:封面图片模拟了中国古代战场。它巧妙地描绘了人体免疫细胞、结核分枝杆菌和糖尿病之间的斗争。免疫细胞和结核分枝杆菌互相厮杀,双方都死伤惨重。然而,糖尿病也会对免疫细胞发起持续攻击,造成免疫细胞的严重损失。封面图片由龚文平、叶朝阳创作。
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引用次数: 0
期刊
Exploration (Beijing, China)
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