Qing-Jiang Xu , Jia-Chen Liu , Cheng-Jin Huang , Xin Wang , Xiao-Ya Shang
{"title":"Triterpene esters of cirsium setosum and their anti-inflammatory activity","authors":"Qing-Jiang Xu , Jia-Chen Liu , Cheng-Jin Huang , Xin Wang , Xiao-Ya Shang","doi":"10.1080/10286020.2024.2340074","DOIUrl":null,"url":null,"abstract":"<div><p>Two new triterpene fatty acid esters, 3<em>β</em>-palmityloxy-12,27-cyclofriedoolean-14-en-11<em>α</em>-ol (<strong>1</strong>) and 3<em>β</em>-palmityloxy-19<em>α</em>-hydroxyursane (<strong>2</strong>), together with 3<em>β</em>-hydroxy-11-oxo-olean-12-enyl palmitate (<strong>3</strong>) were isolated from the potent anti-inflammatory active fraction of the petroleum ether-soluble part of <em>Cirsium setosum</em> ethanol extract. Compound <strong>1</strong> was found to be a rare 12,27-cyclopropane triterpenoid. Their structures were determined through spectral data analysis combined with literature reports. Furthermore, <em>in vitro</em> experiment, compounds <strong>1</strong>-<strong>3</strong> exhibited significant inhibitory effects on nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 macrophages.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asian Natural Products Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S102860202400050X","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Two new triterpene fatty acid esters, 3β-palmityloxy-12,27-cyclofriedoolean-14-en-11α-ol (1) and 3β-palmityloxy-19α-hydroxyursane (2), together with 3β-hydroxy-11-oxo-olean-12-enyl palmitate (3) were isolated from the potent anti-inflammatory active fraction of the petroleum ether-soluble part of Cirsium setosum ethanol extract. Compound 1 was found to be a rare 12,27-cyclopropane triterpenoid. Their structures were determined through spectral data analysis combined with literature reports. Furthermore, in vitro experiment, compounds 1-3 exhibited significant inhibitory effects on nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 macrophages.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
