Immunotherapy and the ovarian cancer microenvironment: Exploring potential strategies for enhanced treatment efficacy

IF 4.9 3区 医学 Q2 IMMUNOLOGY Immunology Pub Date : 2024-04-15 DOI:10.1111/imm.13793
Zhi-Bin Wang, Xiu Zhang, Chao Fang, Xiao-Ting Liu, Qian-Jin Liao, Nayiyuan Wu, Jing Wang
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Abstract

Despite progress in cancer immunotherapy, ovarian cancer (OC) prognosis continues to be disappointing. Recent studies have shed light on how not just tumour cells, but also the complex tumour microenvironment, contribute to this unfavourable outcome of OC immunotherapy. The complexities of the immune microenvironment categorize OC as a ‘cold tumour’. Nonetheless, understanding the precise mechanisms through which the microenvironment influences the effectiveness of OC immunotherapy remains an ongoing scientific endeavour. This review primarily aims to dissect the inherent characteristics and behaviours of diverse cells within the immune microenvironment, along with an exploration into its reprogramming and metabolic changes. It is expected that these insights will elucidate the operational dynamics of the immune microenvironment in OC and lay a theoretical groundwork for improving the efficacy of immunotherapy in OC management.

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免疫疗法与卵巢癌微环境:探索提高疗效的潜在策略
尽管癌症免疫疗法取得了进展,但卵巢癌(OC)的预后仍然令人失望。最近的研究揭示了不仅是肿瘤细胞,复杂的肿瘤微环境也是导致卵巢癌免疫疗法效果不佳的原因。免疫微环境的复杂性将卵巢癌归类为 "冷肿瘤"。然而,了解微环境影响 OC 免疫疗法有效性的确切机制仍是一项持续的科学工作。本综述的主要目的是剖析免疫微环境中各种细胞的固有特征和行为,同时探讨其重塑和代谢变化。希望这些见解能阐明 OC 中免疫微环境的运行动态,并为提高免疫疗法在 OC 治疗中的疗效奠定理论基础。
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来源期刊
Immunology
Immunology 医学-免疫学
CiteScore
11.90
自引率
1.60%
发文量
175
审稿时长
4-8 weeks
期刊介绍: Immunology is one of the longest-established immunology journals and is recognised as one of the leading journals in its field. We have global representation in authors, editors and reviewers. Immunology publishes papers describing original findings in all areas of cellular and molecular immunology. High-quality original articles describing mechanistic insights into fundamental aspects of the immune system are welcome. Topics of interest to the journal include: immune cell development, cancer immunology, systems immunology/omics and informatics, inflammation, immunometabolism, immunology of infection, microbiota and immunity, mucosal immunology, and neuroimmunology. The journal also publishes commissioned review articles on subjects of topical interest to immunologists, and commissions in-depth review series: themed sets of review articles which take a 360° view of select topics at the heart of immunological research.
期刊最新文献
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