Peptides conjugation on biomaterials: chemical conjugation approaches and their promoted multifunction for biomedical applications

IF 2.5 4区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Biotechnology and Bioprocess Engineering Pub Date : 2024-04-02 DOI:10.1007/s12257-024-00095-5
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Abstract

Researchers have made significant efforts to attach peptides to various biomaterials, resulting in diverse functionalities. By harnessing the advantages of peptides, functions such as high specificity, potency, cost-effectiveness, small size for improved tissue penetration and targeted delivery, biodegradability, and novel therapeutic applications can be achieved through their attachment to biomaterials. Of various methods available for modifying biomolecules, chemical techniques are the most established and can effectively immobilize the desired molecule onto a specific surface. This article provides a comprehensive overview of the chemical modification methods used for attaching peptides to various biomaterials in recent studies and showcases some of their latest applications.

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生物材料上的多肽共轭:化学共轭方法及其促进的生物医学应用多功能性
摘要 研究人员在将多肽附着到各种生物材料上方面做出了巨大努力,从而实现了多种功能。利用肽的优势,通过将其附着到生物材料上,可以实现高特异性、高效力、高成本效益、小尺寸以改善组织渗透和靶向递送、生物可降解性和新的治疗应用等功能。在改性生物分子的各种方法中,化学技术最为成熟,可有效地将所需分子固定在特定表面上。本文全面概述了近期研究中用于将肽附着到各种生物材料上的化学修饰方法,并展示了这些方法的一些最新应用。
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来源期刊
Biotechnology and Bioprocess Engineering
Biotechnology and Bioprocess Engineering 工程技术-生物工程与应用微生物
CiteScore
5.00
自引率
12.50%
发文量
79
审稿时长
3 months
期刊介绍: Biotechnology and Bioprocess Engineering is an international bimonthly journal published by the Korean Society for Biotechnology and Bioengineering. BBE is devoted to the advancement in science and technology in the wide area of biotechnology, bioengineering, and (bio)medical engineering. This includes but is not limited to applied molecular and cell biology, engineered biocatalysis and biotransformation, metabolic engineering and systems biology, bioseparation and bioprocess engineering, cell culture technology, environmental and food biotechnology, pharmaceutics and biopharmaceutics, biomaterials engineering, nanobiotechnology, and biosensor and bioelectronics.
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