Existence, Stability and Slow Dynamics of Spikes in a 1D Minimal Keller–Segel Model with Logistic Growth

Abstract

We analyze the existence, linear stability, and slow dynamics of localized 1D spike patterns for a Keller–Segel model of chemotaxis that includes the effect of logistic growth of the cellular population. Our analysis of localized patterns for this two-component reaction–diffusion (RD) model is based, not on the usual limit of a large chemotactic drift coefficient, but instead on the singular limit of an asymptotically small diffusivity \(d_2=\epsilon ^2\ll 1\) of the chemoattractant concentration field. In the limit \(d_2\ll 1\), steady-state and quasi-equilibrium 1D multi-spike patterns are constructed asymptotically. To determine the linear stability of steady-state N-spike patterns, we analyze the spectral properties associated with both the “large” \({{\mathcal {O}}}(1)\) and the “small” o(1) eigenvalues associated with the linearization of the Keller–Segel model. By analyzing a nonlocal eigenvalue problem characterizing the large eigenvalues, it is shown that N-spike equilibria can be destabilized by a zero-eigenvalue crossing leading to a competition instability if the cellular diffusion rate \(d_1\) exceeds a threshold, or from a Hopf bifurcation if a relaxation time constant \(\tau \) is too large. In addition, a matrix eigenvalue problem that governs the stability properties of an N-spike steady-state with respect to the small eigenvalues is derived. From an analysis of this matrix problem, an explicit range of \(d_1\) where the N-spike steady-state is stable to the small eigenvalues is identified. Finally, for quasi-equilibrium spike patterns that are stable on an \({{\mathcal {O}}}(1)\) time-scale, we derive a differential algebraic system (DAE) governing the slow dynamics of a collection of localized spikes. Unexpectedly, our analysis of the KS model with logistic growth in the singular limit \(d_2\ll 1\) is rather closely related to the analysis of spike patterns for the Gierer–Meinhardt RD system.